c2pfam

AT1G12140.1 :

Domain Description Evalue Bits GA Start End
Shikimate_DH Shikimate / quinate 5-dehydrogenase 0.00038 11 24.30 8 43
AlaDh_PNT_C Alanine dehydrogenase/PNT, C-terminal domain 6.8E-05 13 20.30 8 43
IlvN Acetohydroxy acid isomeroreductase, catalytic domain 0.0012 9 20.60 9 42
K_oxygenase L-lysine 6-monooxygenase (NADPH-requiring) 0.19 1 21.00 11 41
Thi4 Thi4 family 3.4E-07 20 20.00 11 49
Pyr_redox Pyridine nucleotide-disulphide oxidoreductase 1.1E-05 17 22.00 12 46
HI0933_like HI0933-like protein 1E-08 25 20.30 12 46
FMO-like Flavin-binding monooxygenase-like 0 130 19.60 12 237
Pyr_redox_2 Pyridine nucleotide-disulphide oxidoreductase 5.1E-17 53 22.80 12 302
NAD_Gly3P_dh_N NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.00044 11 23.10 12 44
FAD_binding_3 FAD binding domain 7.7E-06 16 20.10 12 43
GIDA Glucose inhibited division protein A 2.7E-05 14 20.00 13 42
ApbA Ketopantoate reductase PanE/ApbA 0.0003 11 21.70 13 43
Lycopene_cycl Lycopene cyclase protein 0.00029 10 23.40 13 40
TrkA_N TrkA-N domain 2.7E-05 15 21.70 13 44
DAO FAD dependent oxidoreductase 1.2E-08 25 24.70 13 46
FAD_binding_2 FAD binding domain 1.1E-08 25 20.40 13 47
FAD_oxidored FAD dependent oxidoreductase 1.1E-07 22 27.00 13 81
NAD_binding_9 FAD-NAD(P)-binding 1.3E-10 32 21.80 14 172
Pyr_redox_3 Pyridine nucleotide-disulphide oxidoreductase 2E-05 14 30.00 15 45
NAD_binding_8 NAD(P)-binding Rossmann-like domain 3.5E-12 37 21.90 15 49
Amino_oxidase Flavin containing amine oxidoreductase 2.5E-08 24 19.80 21 108
Pyr_redox_3 Pyridine nucleotide-disulphide oxidoreductase 4.1E-20 63 30.00 81 303
K_oxygenase L-lysine 6-monooxygenase (NADPH-requiring) 8.6E-10 29 21.00 105 245
DAO FAD dependent oxidoreductase 7.5E-06 16 24.70 131 203
ApbA Ketopantoate reductase PanE/ApbA 1 -1 21.70 135 169
Shikimate_DH Shikimate / quinate 5-dehydrogenase 0.71 1 24.30 201 238
Pyr_redox Pyridine nucleotide-disulphide oxidoreductase 0.35 2 22.00 208 238
Lycopene_cycl Lycopene cyclase protein 0.91 -1 23.40 253 285
FMO-like Flavin-binding monooxygenase-like 2.8E-21 66 19.60 255 403
NAD_binding_9 FAD-NAD(P)-binding 0.18 2 21.80 262 286
GIDA Glucose inhibited division protein A 0.69 -1 20.00 266 304
K_oxygenase L-lysine 6-monooxygenase (NADPH-requiring) 0.19 1 21.00 271 287

459

Shikimate_DH
AlaDh_PNT_C
IlvN
K_oxygenase
Thi4
Pyr_redox
HI0933_like
FMO-like
Pyr_redox_2
NAD_Gly3P_dh_N
FAD_binding_3
GIDA
ApbA
Lycopene_cycl
TrkA_N
DAO
FAD_binding_2
FAD_oxidored
NAD_binding_9
Pyr_redox_3
NAD_binding_8
Amino_oxidase
Pyr_redox_3
K_oxygenase
DAO
ApbA
Shikimate_DH
Pyr_redox
Lycopene_cycl
FMO-like
NAD_binding_9
GIDA
K_oxygenase

References:

TrkA_N
9478130 A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease. Trends Biochem Sci 1998;23:17-19.
8412700 NAD+ binding to the Escherichia coli K(+)-uptake protein TrkA and sequence similarity between TrkA and domains of a family of dehydrogenases suggest a role for NAD+ in bacterial transport. Mol Microbiol 1993;9:533-543.
11292341 Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. J Mol Biol 2001;307:1271-1292.

Shikimate_DH
7556173 The molecular biology of multidomain proteins. Selected examples. Eur J Biochem 1995;232:7-18.

Amino_oxidase
9598979 Maize polyamine oxidase: primary structure from protein and cDNA sequencing. FEBS Lett 1998;426:62-66.
9162023 A key amino acid responsible for substrate selectivity of monoamine oxidase A and B. J Biol Chem 1997;272:14033-14036.
7770050 Cloning, sequencing and heterologous expression of the monoamine oxidase gene from Aspergillus niger. Mol Gen Genet 1995;247:430-438.

FAD_binding_2
8061609 Structure of glutathione reductase from Escherichia coli at 1.86 A resolution: comparison with the enzyme from human erythrocytes. Protein Sci 1994;3:799-809.

FMO-like
9538688 A hydrophobic sequence motif common to N-hydroxylating enzymes. Trends Biochem Sci 1998;23:56-57.

IlvN
9218783 The crystal structure of plant acetohydroxy acid isomeroreductase complexed with NADPH, two magnesium ions and a herbicidal transition state analog determined at 1.65 A resolution. EMBO J 1997;16:3405-3415.

Lycopene_cycl
8837512 Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation. Plant Cell 1996;8:1613-1626.
11226339 One ring or two? Determination of ring number in carotenoids by lycopene epsilon-cyclases. Proc Natl Acad Sci U S A 2001;98:2905-2910.

ApbA
9488683 ApbA, the ketopantoate reductase enzyme of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway. J Biol Chem 1998;273:5572-5576.
9721324 The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium. J Bacteriol 1998;180:4757-4759.

Thi4
7961415 Cloning, nucleotide sequence, and regulation of Schizosaccharomyces pombe thi4, a thiamine biosynthetic gene. J Bacteriol 1994;176:6631-6635.

FAD_binding_3
1409567 Crystal structure of the reduced form of p-hydroxybenzoate hydroxylase refined at 2.3A resolution. Proteins 1992;14:178-190.

Pyr_redox_2
8805537 Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. Structure 1996;4:277-286.

Pyr_redox
8805537 Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. Structure 1996;4:277-286.

DAO
9153426 Active site plasticity in D-amino acid oxidase: a crystallographic analysis. Biochemistry 1997;36:5853-5860.

HI0933_like

Pyr_redox_3

FAD_oxidored

AlaDh_PNT_C
11354603 Lysine metabolism in higher plants. Amino Acids 2001;20:261-279.

K_oxygenase

GIDA

NAD_binding_9

NAD_binding_8

NAD_Gly3P_dh_N
12032156 Kinetic regulation of the mitochondrial glycerol-3-phosphate dehydrogenase by the external NADH dehydrogenase in Saccharomyces cerevisiae. J Biol Chem 2002;277:27991-27995.
10801498 A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana. Structure Fold Des 2000;8:541-552.

Domain	Description	Evalue	Bits	GA	Start	End
Shikimate_DH	Shikimate / quinate 5-dehydrogenase	0.00038	11	24.30	8	43
AlaDh_PNT_C	Alanine dehydrogenase/PNT, C-terminal domain	6.8E-05	13	20.30	8	43
IlvN	Acetohydroxy acid isomeroreductase, catalytic domain	0.0012	9	20.60	9	42
K_oxygenase	L-lysine 6-monooxygenase (NADPH-requiring)	0.19	1	21.00	11	41
Thi4	Thi4 family	3.4E-07	20	20.00	11	49
Pyr_redox	Pyridine nucleotide-disulphide oxidoreductase	1.1E-05	17	22.00	12	46
HI0933_like	HI0933-like protein	1E-08	25	20.30	12	46
FMO-like	Flavin-binding monooxygenase-like	0	130	19.60	12	237
Pyr_redox_2	Pyridine nucleotide-disulphide oxidoreductase	5.1E-17	53	22.80	12	302
NAD_Gly3P_dh_N	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus	0.00044	11	23.10	12	44
FAD_binding_3	FAD binding domain	7.7E-06	16	20.10	12	43
GIDA	Glucose inhibited division protein A	2.7E-05	14	20.00	13	42
ApbA	Ketopantoate reductase PanE/ApbA	0.0003	11	21.70	13	43
Lycopene_cycl	Lycopene cyclase protein	0.00029	10	23.40	13	40
TrkA_N	TrkA-N domain	2.7E-05	15	21.70	13	44
DAO	FAD dependent oxidoreductase	1.2E-08	25	24.70	13	46
FAD_binding_2	FAD binding domain	1.1E-08	25	20.40	13	47
FAD_oxidored	FAD dependent oxidoreductase	1.1E-07	22	27.00	13	81
NAD_binding_9	FAD-NAD(P)-binding	1.3E-10	32	21.80	14	172
Pyr_redox_3	Pyridine nucleotide-disulphide oxidoreductase	2E-05	14	30.00	15	45
NAD_binding_8	NAD(P)-binding Rossmann-like domain	3.5E-12	37	21.90	15	49
Amino_oxidase	Flavin containing amine oxidoreductase	2.5E-08	24	19.80	21	108
Pyr_redox_3	Pyridine nucleotide-disulphide oxidoreductase	4.1E-20	63	30.00	81	303
K_oxygenase	L-lysine 6-monooxygenase (NADPH-requiring)	8.6E-10	29	21.00	105	245
DAO	FAD dependent oxidoreductase	7.5E-06	16	24.70	131	203
ApbA	Ketopantoate reductase PanE/ApbA	1	-1	21.70	135	169
Shikimate_DH	Shikimate / quinate 5-dehydrogenase	0.71	1	24.30	201	238
Pyr_redox	Pyridine nucleotide-disulphide oxidoreductase	0.35	2	22.00	208	238
Lycopene_cycl	Lycopene cyclase protein	0.91	-1	23.40	253	285
FMO-like	Flavin-binding monooxygenase-like	2.8E-21	66	19.60	255	403
NAD_binding_9	FAD-NAD(P)-binding	0.18	2	21.80	262	286
GIDA	Glucose inhibited division protein A	0.69	-1	20.00	266	304
K_oxygenase	L-lysine 6-monooxygenase (NADPH-requiring)	0.19	1	21.00	271	287