c2pfam

AT1G02690.1 :

Domain Description Evalue Bits GA Start End
IBB Importin beta binding domain 9.9E-27 83 23.60 12 97
DUF4715 Domain of unknown function (DUF4715) 1.3E-05 15 27.00 62 103
Arm Armadillo/beta-catenin-like repeat 8.5E-14 41 20.60 109 149
RICTOR_V Rapamycin-insensitive companion of mTOR, domain 5 0.02 5 27.00 117 149
HEAT HEAT repeat 0.0076 7 23.50 120 150
HEAT_2 HEAT repeats 5.7E-11 33 27.70 121 191
V-ATPase_H_C V-ATPase subunit H 0.052 4 20.80 123 188
HEAT_EZ HEAT-like repeat 5.9E-11 33 27.00 135 188
HEAT_PBS PBS lyase HEAT-like repeat 0.44 2 20.90 137 149
Arm_2 Armadillo-like 0.00028 10 20.40 141 190
RICTOR_V Rapamycin-insensitive companion of mTOR, domain 5 0.003 8 27.00 141 191
Arm_2 Armadillo-like 8E-05 12 20.40 151 219
Arm Armadillo/beta-catenin-like repeat 2.5E-16 49 20.60 151 190
NopRA1 Nucleolar pre-ribosomal-associated protein 1 0.0022 7 29.60 159 188
Adaptin_N Adaptin N terminal region 8.8E-05 11 20.30 163 238
HEAT HEAT repeat 6E-08 23 23.50 164 190
RasGEF_N_2 Rapamycin-insensitive companion of mTOR RasGEF_N domain 0.0058 7 27.00 164 211
HEAT_PBS PBS lyase HEAT-like repeat 0.0039 8 20.90 178 191
RICTOR_V Rapamycin-insensitive companion of mTOR, domain 5 0.015 6 27.00 181 224
Arm Armadillo/beta-catenin-like repeat 1.3E-07 22 20.60 193 234
HEAT_2 HEAT repeats 0.00026 11 27.70 215 281
HEAT_EZ HEAT-like repeat 3.6E-07 21 27.00 223 273
HEAT_PBS PBS lyase HEAT-like repeat 0.028 5 20.90 223 255
V-ATPase_H_C V-ATPase subunit H 0.0013 9 20.80 245 316
NopRA1 Nucleolar pre-ribosomal-associated protein 1 9E-05 12 29.60 247 280
Adaptin_N Adaptin N terminal region 1.1E-05 14 20.30 247 494
Arm Armadillo/beta-catenin-like repeat 2.2E-09 27 20.60 247 275
HEAT HEAT repeat 0.018 6 23.50 248 274
Arm Armadillo/beta-catenin-like repeat 3.4E-14 42 20.60 278 316
Arm_2 Armadillo-like 0.29 0 20.40 282 322
HEAT HEAT repeat 0.00029 11 23.50 289 317
HEAT_EZ HEAT-like repeat 0.0018 9 27.00 289 315
HEAT_2 HEAT repeats 1.1E-05 16 27.70 290 359
RasGEF_N_2 Rapamycin-insensitive companion of mTOR RasGEF_N domain 0.38 1 27.00 290 330
HEAT_EZ HEAT-like repeat 1.3E-05 16 27.00 308 358
HEAT_PBS PBS lyase HEAT-like repeat 0.19 3 20.90 308 341
Arm Armadillo/beta-catenin-like repeat 4.8E-12 36 20.60 322 360
Arm_2 Armadillo-like 4.1E-07 20 20.40 323 418
NopRA1 Nucleolar pre-ribosomal-associated protein 1 0.12 2 29.60 325 364
HEAT HEAT repeat 0.22 2 23.50 332 359
HEAT_2 HEAT repeats 0.00083 10 27.70 332 412
V-ATPase_H_C V-ATPase subunit H 0.3 1 20.80 333 399
RICTOR_V Rapamycin-insensitive companion of mTOR, domain 5 0.93 0 27.00 348 362
HEAT_EZ HEAT-like repeat 4.3E-05 14 27.00 348 399
Arm Armadillo/beta-catenin-like repeat 7.8E-13 38 20.60 363 401
HEAT_EZ HEAT-like repeat 0.29 2 27.00 390 401
RICTOR_V Rapamycin-insensitive companion of mTOR, domain 5 0.69 0 27.00 390 402
Arm Armadillo/beta-catenin-like repeat 3.8E-09 26 20.60 405 443
HEAT HEAT repeat 0.69 1 23.50 421 446
Arm_2 Armadillo-like 0.00052 9 20.40 453 504
Arm_3 Atypical Arm repeat 1.6E-24 75 28.80 460 506
V-ATPase_H_C V-ATPase subunit H 0.094 3 20.80 463 494
HEAT_2 HEAT repeats 0.64 1 27.70 470 494
RasGEF_N_2 Rapamycin-insensitive companion of mTOR RasGEF_N domain 0.23 2 27.00 481 501

538

IBB
DUF4715
Arm
RICTOR_V
HEAT
HEAT_2
V-ATPase_H_C
HEAT_EZ
HEAT_PBS
Arm_2
RICTOR_V
Arm_2
Arm
NopRA1
Adaptin_N
HEAT
RasGEF_N_2
HEAT_PBS
RICTOR_V
Arm
HEAT_2
HEAT_EZ
HEAT_PBS
V-ATPase_H_C
NopRA1
Adaptin_N
Arm
HEAT
Arm
Arm_2
HEAT
HEAT_EZ
HEAT_2
RasGEF_N_2
HEAT_EZ
HEAT_PBS
Arm
Arm_2
NopRA1
HEAT
HEAT_2
V-ATPase_H_C
RICTOR_V
HEAT_EZ
Arm
HEAT_EZ
RICTOR_V
Arm
HEAT
Arm_2
Arm_3
V-ATPase_H_C
HEAT_2
RasGEF_N_2

References:

RICTOR_V

V-ATPase_H_C
10954728 Regulation of yeast ectoapyrase ynd1p activity by activator subunit Vma13p of vacuolar H+-ATPase. J Biol Chem 2000;275:35592-35599.
18708638 Functional characterization of the N-terminal domain of subunit H (Vma13p) of the yeast vacuolar ATPase. J Biol Chem. 2008; [Epub ahead of print]
16141210 Structural and functional separation of the N- and C-terminal domains of the yeast V-ATPase subunit H. J Biol Chem. 2005;280:36978-36985.

Arm_2

RasGEF_N_2

Arm
9298899 Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell 1997;90:871-882.
8573337 Signal transduction of beta-catenin. Curr Opin Cell Biol 1995;7:634-640.
9309175 Armadillo and dTCF: a marriage made in the nucleus. Curr Opin Genet Dev 1997;7:459-466.
8259519 Association of the APC tumor suppressor protein with catenins. Science 1993;262:1734-1737.
8259518 Association of the APC gene product with beta-catenin. Science 1993;262:1731-1734.
2261639 The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell 1990;63:1167-1176.

IBB
9695948 Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell 1998;94:193-204.
9612083 Importins and exportins: how to get in and out of the nucleus [published erratum appears in Trends Biochem Sci 1998 Jul;23(7):235] Trends Biochem Sci 1998;23:185-189.
9582265 Transport into and out of the cell nucleus. EMBO J 1998;17:2721-2727.
8692858 The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence. Proc Natl Acad Sci U S A 1996;93:6572-6576.
8617226 A 41 amino acid motif in importin-alpha confers binding to importin- beta and hence transit into the nucleus. EMBO J 1996;15:1810-1817.

HEAT_PBS
8132596 Oligomeric structure, enzyme kinetics, and substrate specificity of the phycocyanin alpha subunit phycocyanobilin lyase. J Biol Chem 1994;269:8686-8694.
9023176 A role for cpeYZ in cyanobacterial phycoerythrin biosynthesis. J Bacteriol 1997;179:998-1006.
10708746 Novel activity of a phycobiliprotein lyase: both the attachment of phycocyanobilin and the isomerization to phycoviolobilin are catalyzed by the proteins PecE and PecF encoded by the phycoerythrocyanin operon. FEBS Lett 2000;469:9-13.
9882677 A polypeptide with similarity to phycocyanin alpha-subunit phycocyanobilin lyase involved in degradation of phycobilisomes. J Bacteriol 1999;181:610-617.

HEAT
7550332 HEAT repeats in the Huntington's disease protein. Nat Genet 1995;11:115-116.
9989501 The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell 1999;96:99-110.

HEAT_EZ

HEAT_2

NopRA1

Arm_3

DUF4715

Adaptin_N
9261055 Linking cargo to vesicle formation: receptor tail interactions with coat proteins. Curr Opin Cell Biol 1997;9:488-495.
2495531 Structural and functional division into two domains of the large (100- to 115-kDa)chains of the clathrin-associated protein complex AP-2. Proc Natl Acad Sci U S A 1989;86:2612-2616.

Domain	Description	Evalue	Bits	GA	Start	End
IBB	Importin beta binding domain	9.9E-27	83	23.60	12	97
DUF4715	Domain of unknown function (DUF4715)	1.3E-05	15	27.00	62	103
Arm	Armadillo/beta-catenin-like repeat	8.5E-14	41	20.60	109	149
RICTOR_V	Rapamycin-insensitive companion of mTOR, domain 5	0.02	5	27.00	117	149
HEAT	HEAT repeat	0.0076	7	23.50	120	150
HEAT_2	HEAT repeats	5.7E-11	33	27.70	121	191
V-ATPase_H_C	V-ATPase subunit H	0.052	4	20.80	123	188
HEAT_EZ	HEAT-like repeat	5.9E-11	33	27.00	135	188
HEAT_PBS	PBS lyase HEAT-like repeat	0.44	2	20.90	137	149
Arm_2	Armadillo-like	0.00028	10	20.40	141	190
RICTOR_V	Rapamycin-insensitive companion of mTOR, domain 5	0.003	8	27.00	141	191
Arm_2	Armadillo-like	8E-05	12	20.40	151	219
Arm	Armadillo/beta-catenin-like repeat	2.5E-16	49	20.60	151	190
NopRA1	Nucleolar pre-ribosomal-associated protein 1	0.0022	7	29.60	159	188
Adaptin_N	Adaptin N terminal region	8.8E-05	11	20.30	163	238
HEAT	HEAT repeat	6E-08	23	23.50	164	190
RasGEF_N_2	Rapamycin-insensitive companion of mTOR RasGEF_N domain	0.0058	7	27.00	164	211
HEAT_PBS	PBS lyase HEAT-like repeat	0.0039	8	20.90	178	191
RICTOR_V	Rapamycin-insensitive companion of mTOR, domain 5	0.015	6	27.00	181	224
Arm	Armadillo/beta-catenin-like repeat	1.3E-07	22	20.60	193	234
HEAT_2	HEAT repeats	0.00026	11	27.70	215	281
HEAT_EZ	HEAT-like repeat	3.6E-07	21	27.00	223	273
HEAT_PBS	PBS lyase HEAT-like repeat	0.028	5	20.90	223	255
V-ATPase_H_C	V-ATPase subunit H	0.0013	9	20.80	245	316
NopRA1	Nucleolar pre-ribosomal-associated protein 1	9E-05	12	29.60	247	280
Adaptin_N	Adaptin N terminal region	1.1E-05	14	20.30	247	494
Arm	Armadillo/beta-catenin-like repeat	2.2E-09	27	20.60	247	275
HEAT	HEAT repeat	0.018	6	23.50	248	274
Arm	Armadillo/beta-catenin-like repeat	3.4E-14	42	20.60	278	316
Arm_2	Armadillo-like	0.29	0	20.40	282	322
HEAT	HEAT repeat	0.00029	11	23.50	289	317
HEAT_EZ	HEAT-like repeat	0.0018	9	27.00	289	315
HEAT_2	HEAT repeats	1.1E-05	16	27.70	290	359
RasGEF_N_2	Rapamycin-insensitive companion of mTOR RasGEF_N domain	0.38	1	27.00	290	330
HEAT_EZ	HEAT-like repeat	1.3E-05	16	27.00	308	358
HEAT_PBS	PBS lyase HEAT-like repeat	0.19	3	20.90	308	341
Arm	Armadillo/beta-catenin-like repeat	4.8E-12	36	20.60	322	360
Arm_2	Armadillo-like	4.1E-07	20	20.40	323	418
NopRA1	Nucleolar pre-ribosomal-associated protein 1	0.12	2	29.60	325	364
HEAT	HEAT repeat	0.22	2	23.50	332	359
HEAT_2	HEAT repeats	0.00083	10	27.70	332	412
V-ATPase_H_C	V-ATPase subunit H	0.3	1	20.80	333	399
RICTOR_V	Rapamycin-insensitive companion of mTOR, domain 5	0.93	0	27.00	348	362
HEAT_EZ	HEAT-like repeat	4.3E-05	14	27.00	348	399
Arm	Armadillo/beta-catenin-like repeat	7.8E-13	38	20.60	363	401
HEAT_EZ	HEAT-like repeat	0.29	2	27.00	390	401
RICTOR_V	Rapamycin-insensitive companion of mTOR, domain 5	0.69	0	27.00	390	402
Arm	Armadillo/beta-catenin-like repeat	3.8E-09	26	20.60	405	443
HEAT	HEAT repeat	0.69	1	23.50	421	446
Arm_2	Armadillo-like	0.00052	9	20.40	453	504
Arm_3	Atypical Arm repeat	1.6E-24	75	28.80	460	506
V-ATPase_H_C	V-ATPase subunit H	0.094	3	20.80	463	494
HEAT_2	HEAT repeats	0.64	1	27.70	470	494
RasGEF_N_2	Rapamycin-insensitive companion of mTOR RasGEF_N domain	0.23	2	27.00	481	501