c2pfam

AT4G18050.1 :

Domain Description Evalue Bits GA Start End
ABC_membrane ABC transporter transmembrane region 0 203 22.00 33 305
ABC_tran ABC transporter 7.9E-38 122 23.10 376 522
AAA_7 P-loop containing dynein motor region 0.00049 11 25.80 376 410
AAA_25 AAA domain 0.0022 9 27.00 379 400
TruB_C tRNA Pseudouridine synthase II, C terminal 0.065 5 21.60 379 399
DLIC Dynein light intermediate chain (DLIC) 0.0087 6 19.30 380 413
Sigma54_activat Sigma-54 interaction domain 0.05 5 20.20 381 410
AAA_29 P-loop containing region of AAA domain 2.2E-05 16 27.00 381 400
ATPase KaiC 0.073 4 26.60 381 399
TsaE Threonylcarbamoyl adenosine biosynthesis protein TsaE 0.18 3 26.60 381 403
DEAD DEAD/DEAH box helicase 8.2E-05 14 20.60 382 539
RsgA_GTPase RsgA GTPase 0.00013 14 30.00 382 404
ATP-synt_ab ATP synthase alpha/beta family, nucleotide-binding domain 0.46 2 20.30 382 405
AAA_23 AAA domain 0.0084 8 27.00 382 403
AAA_24 AAA domain 0.003 9 27.00 383 417
APS_kinase Adenylylsulphate kinase 0.016 7 20.70 383 405
KAP_NTPase KAP family P-loop domain 0.013 6 20.00 383 490
P-loop_TraG TraG P-loop domain 0.023 5 25.80 384 417
AAA_10 AAA-like domain 0.0083 7 27.50 384 431
DUF815 Protein of unknown function (DUF815) 0.0016 9 20.10 384 468
AAA_30 AAA domain 0.0005 11 27.00 384 415
AAA_16 AAA ATPase domain 3.3E-05 16 32.60 384 539
Zeta_toxin Zeta toxin 1.8E-05 16 20.10 385 424
AAA_15 AAA ATPase domain 0.00018 13 32.10 385 469
Ploopntkinase3 P-loop Nucleotide Kinase3 0.0039 8 27.00 385 410
NACHT NACHT domain 0.034 6 20.40 385 400
NB-ARC NB-ARC domain 0.028 5 23.50 385 403
SRP54 SRP54-type protein, GTPase domain 0.014 7 20.50 385 431
AAA_33 AAA domain 0.027 6 27.00 386 401
NTPase_1 NTPase 0.17 3 23.90 386 403
Roc Ras of Complex, Roc, domain of DAPkinase 0.073 5 27.00 386 406
Dynamin_N Dynamin family 0.052 5 21.00 386 401
AAA_18 AAA domain 0.0068 9 29.40 386 424
PRK Phosphoribulokinase / Uridine kinase family 0.017 6 20.60 386 407
Gtr1_RagA Gtr1/RagA G protein conserved region 0.0044 8 20.10 386 428
AAA_5 AAA domain (dynein-related subfamily) 0.0028 9 20.80 386 431
MMR_HSR1 GTPase of unknown function 0.0096 8 24.50 386 403
G-alpha G-protein alpha subunit 0.00022 12 20.10 386 410
DUF87 Domain of unknown function DUF87 0.0009 11 20.90 386 417
AAA_22 AAA domain 4.1E-05 16 27.00 386 535
SMC_N RecF/RecN/SMC N terminal domain 8.4E-07 20 40.00 387 566
AAA_21 AAA domain, putative AbiEii toxin, Type IV TA system 0.00061 11 27.00 387 430
RNA_helicase RNA helicase 0.15 4 21.50 387 402
AAA ATPase family associated with various cellular activities (AAA) 0.00068 12 20.80 388 546
AAA_17 AAA domain 0.042 6 27.00 389 419
ABC_ATPase Predicted ATPase of the ABC class 2.1E-06 18 19.30 464 524
SbcCD_C Putative exonuclease SbcCD, C subunit 0.0043 9 27.00 493 535
ABC_membrane ABC transporter transmembrane region 0 156 22.00 687 943
ABC_tran ABC transporter 2.9E-37 120 23.10 1013 1161
ATP-synt_ab ATP synthase alpha/beta family, nucleotide-binding domain 0.0012 10 20.30 1013 1187
TsaE Threonylcarbamoyl adenosine biosynthesis protein TsaE 0.043 5 26.60 1014 1043
AAA_29 P-loop containing region of AAA domain 2.1E-05 16 27.00 1016 1038
AAA_7 P-loop containing dynein motor region 0.0021 9 25.80 1017 1046
DEAD DEAD/DEAH box helicase 0.00023 13 20.60 1017 1178
Sigma54_activat Sigma-54 interaction domain 0.014 7 20.20 1017 1046
AAA_25 AAA domain 0.0067 8 27.00 1018 1038
DLIC Dynein light intermediate chain (DLIC) 0.00072 10 19.30 1018 1046
ATPase KaiC 0.019 6 26.60 1018 1037
TruB_C tRNA Pseudouridine synthase II, C terminal 0.057 5 21.60 1019 1037
AAA_16 AAA ATPase domain 2.1E-05 17 32.60 1019 1070
RsgA_GTPase RsgA GTPase 0.00032 12 30.00 1020 1042
AAA_30 AAA domain 0.0009 11 27.00 1020 1174
AAA_23 AAA domain 0.0085 8 27.00 1020 1041
AAA_24 AAA domain 0.0031 9 27.00 1021 1043
APS_kinase Adenylylsulphate kinase 0.017 7 20.70 1021 1044
KAP_NTPase KAP family P-loop domain 0.067 4 20.00 1021 1075
P-loop_TraG TraG P-loop domain 0.012 6 25.80 1022 1055
DUF815 Protein of unknown function (DUF815) 0.0022 9 20.10 1022 1078
AAA_15 AAA ATPase domain 7.8E-05 14 32.10 1022 1061
Zeta_toxin Zeta toxin 0.00084 10 20.10 1022 1060
SMC_N RecF/RecN/SMC N terminal domain 0.026 6 40.00 1022 1041
SRP54 SRP54-type protein, GTPase domain 0.067 4 20.50 1023 1054
NB-ARC NB-ARC domain 0.031 5 23.50 1023 1041
NACHT NACHT domain 0.022 6 20.40 1023 1039
AAA_10 AAA-like domain 0.11 3 27.50 1024 1053
AAA_33 AAA domain 0.053 5 27.00 1024 1038
Dynamin_N Dynamin family 0.048 5 21.00 1024 1041
Roc Ras of Complex, Roc, domain of DAPkinase 0.057 5 27.00 1024 1040
NTPase_1 NTPase 0.096 4 23.90 1024 1041
AAA_22 AAA domain 0.00036 13 27.00 1024 1047
G-alpha G-protein alpha subunit 0.00022 12 20.10 1024 1054
DUF87 Domain of unknown function DUF87 0.0016 10 20.90 1024 1054
AAA_5 AAA domain (dynein-related subfamily) 0.01 7 20.80 1024 1046
MMR_HSR1 GTPase of unknown function 0.009 8 24.50 1024 1041
AAA_18 AAA domain 0.073 5 29.40 1024 1042
Ploopntkinase3 P-loop Nucleotide Kinase3 0.029 6 27.00 1024 1045
Gtr1_RagA Gtr1/RagA G protein conserved region 0.048 5 20.10 1024 1052
PRK Phosphoribulokinase / Uridine kinase family 0.0095 7 20.60 1024 1046
AAA_21 AAA domain, putative AbiEii toxin, Type IV TA system 0.015 7 27.00 1025 1045
RNA_helicase RNA helicase 0.094 5 21.50 1025 1040
AAA ATPase family associated with various cellular activities (AAA) 0.014 7 20.80 1026 1184
AAA_17 AAA domain 0.18 4 27.00 1027 1046
SMC_N RecF/RecN/SMC N terminal domain 1.7E-06 19 40.00 1082 1204
ABC_ATPase Predicted ATPase of the ABC class 1.7E-05 15 19.30 1108 1163
SbcCD_C Putative exonuclease SbcCD, C subunit 0.0057 9 27.00 1149 1175

1236

ABC_membrane
ABC_tran
AAA_7
AAA_25
TruB_C
DLIC
Sigma54_activat
AAA_29
ATPase
TsaE
DEAD
RsgA_GTPase
ATP-synt_ab
AAA_23
AAA_24
APS_kinase
KAP_NTPase
P-loop_TraG
AAA_10
DUF815
AAA_30
AAA_16
Zeta_toxin
AAA_15
Ploopntkinase3
NACHT
NB-ARC
SRP54
AAA_33
NTPase_1
Roc
Dynamin_N
AAA_18
PRK
Gtr1_RagA
AAA_5
MMR_HSR1
G-alpha
DUF87
AAA_22
SMC_N
AAA_21
RNA_helicase
AAA
AAA_17
ABC_ATPase
SbcCD_C
ABC_membrane
ABC_tran
ATP-synt_ab
TsaE
AAA_29
AAA_7
DEAD
Sigma54_activat
AAA_25
DLIC
ATPase
TruB_C
AAA_16
RsgA_GTPase
AAA_30
AAA_23
AAA_24
APS_kinase
KAP_NTPase
P-loop_TraG
DUF815
AAA_15
Zeta_toxin
SMC_N
SRP54
NB-ARC
NACHT
AAA_10
AAA_33
Dynamin_N
Roc
NTPase_1
AAA_22
G-alpha
DUF87
AAA_5
MMR_HSR1
AAA_18
Ploopntkinase3
Gtr1_RagA
PRK
AAA_21
RNA_helicase
AAA
AAA_17
SMC_N
ABC_ATPase
SbcCD_C

References:

MMR_HSR1
8180467 Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. Mamm Genome 1994;5:100-105.

RsgA_GTPase

TruB_C
15028724 Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft. J Biol Chem. 2004;279:24585-24591.

SbcCD_C

P-loop_TraG

Zeta_toxin
12571357 Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation. Proc Natl Acad Sci U S A 2003;100:1661-1666.

TsaE

DEAD
10322435 Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 1999;24:192-198.
9862990 The DEAD box RNA helicase family in Arabidopsis thaliana. Nucleic Acids Res 1999;27:628-636.

ATP-synt_ab
8065448 Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria. Nature 1994;370:621-628.
9261073 The crystal structure of the nucleotide-free alpha 3 beta 3 subcomplex of F1-ATPase from the thermophilic Bacillus PS3 is a symmetric trimer. Structure 1997;5:825-836.

PRK
9548738 The crystal structure of phosphoribulokinase from Rhodobacter sphaeroides reveals a fold similar to that of adenylate kinase. Biochemistry 1998;37:5074-5085.
17143579 Functional characterization of a gene encoding a dual domain for uridine kinase and uracil phosphoribosyltransferase in Arabidopsis thaliana. Plant Mol Biol. 2007;63:465-477.

RNA_helicase
2546125 Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res 1989;17:4713-4730.

SRP54
9002525 Crystal structure of the NG domain from the signal-recognition particle receptor FtsY. Nature 1997;385:365-368.

G-alpha
8073283 Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science 1994;265:1405-1412.
8851656 How G proteins work: a continuing story. Trends Biochem Sci 1996;21:41-44.

NTPase_1

ATPase

AAA
7646486 A 200-amino acid ATPase module in search of a basic function. Bioessays 1995;17:639-650.
9927482 AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res 1999;9:27-43.

DUF815

ABC_tran
1864505 Homology between proteins controlling Streptomyces fradiae tylosin resistance and ATP-binding transport. Gene 1991;102:27-32.
1977073 Structure and function of haemolysin B,P-glycoprotein and other members of a novel family of membrane translocators. Mol Microbiol 1990;4:873-880.
2229036 Binding protein-dependent transport systems. J Bioenerg Biomembr 1990;22:571-592.
9872322 Crystal structure of the ATP-binding subunit of an ABC transporter. Nature 1998;396:703-707.

KAP_NTPase
15128444 A novel family of P-loop NTPases with an unusual phyletic distribution and transmembrane segments inserted within the NTPase domain. Genome Biol 2004;5:R30.

AAA_7

Roc

NACHT
10782090 The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation. Trends Biochem Sci 2000;25:223-224.

AAA_33

Ploopntkinase3

AAA_30

AAA_29

Sigma54_activat
11544185 Binding of transcriptional activators to sigma 54 in the presence of the transition state analog ADP-aluminum fluoride: insights into activator mechanochemical action. Genes Dev 2001;15:2282-2294.
12618438 Domain Architectures of sigma(54)-Dependent Transcriptional Activators. J Bacteriol 2003;185:1757-1767.

AAA_5
7646486 A 200-amino acid ATPase module in search of a basic function. Bioessays 1995;17:639-650.
9927482 AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res 1999;9:27-43.

AAA_25

AAA_24

AAA_23

AAA_22

AAA_21

Dynamin_N
8939066 Dynamin GTPase, a force-generating molecular switch. Bioessays 1996;18:885-893.
2144893 Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins. Nature 1990;347:256-261.

AAA_18

AAA_17

AAA_16

AAA_15

APS_kinase
9786849 Adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum. site- directed mutagenesis at putative phosphoryl-accepting and ATP P-loop residues. J Biol Chem 1998;273:28583-28589.

AAA_10

ABC_membrane

ABC_ATPase

NB-ARC
9545207 The NB-ARC domain: a novel signalling motif shared by plant resistance gene products and regulators of cell death in animals. Curr Biol 1998;8:226-227.

SMC_N
10429180 Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Eur J Biochem 1999;263:6-13.
9640531 SMC protein complexes and higher-order chromosome dynamics. Curr Opin Cell Biol 1998;10:317-322.

DUF87

DLIC
10545494 Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organization. J Cell Biol 1999;147:481-492.
10893222 Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin. J Biol Chem 2000;275:32763-32768.
11907264 Identification of a novel light intermediate chain (D2LIC) for mammalian cytoplasmic dynein 2. Mol Biol Cell 2002;13:817-829.

Gtr1_RagA
1620108 Putative GTP-binding protein, Gtr1, associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces cerevisiae. Mol Cell Biol 1992;12:2958-2966.
7499430 Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases. J Biol Chem 1995;270:28982-28988.
10388807 Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p. Genetics 1999;152:853-867.
11073942 Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. J Biol Chem 2001;276:7246-7257.

Domain	Description	Evalue	Bits	GA	Start	End
ABC_membrane	ABC transporter transmembrane region	0	203	22.00	33	305
ABC_tran	ABC transporter	7.9E-38	122	23.10	376	522
AAA_7	P-loop containing dynein motor region	0.00049	11	25.80	376	410
AAA_25	AAA domain	0.0022	9	27.00	379	400
TruB_C	tRNA Pseudouridine synthase II, C terminal	0.065	5	21.60	379	399
DLIC	Dynein light intermediate chain (DLIC)	0.0087	6	19.30	380	413
Sigma54_activat	Sigma-54 interaction domain	0.05	5	20.20	381	410
AAA_29	P-loop containing region of AAA domain	2.2E-05	16	27.00	381	400
ATPase	KaiC	0.073	4	26.60	381	399
TsaE	Threonylcarbamoyl adenosine biosynthesis protein TsaE	0.18	3	26.60	381	403
DEAD	DEAD/DEAH box helicase	8.2E-05	14	20.60	382	539
RsgA_GTPase	RsgA GTPase	0.00013	14	30.00	382	404
ATP-synt_ab	ATP synthase alpha/beta family, nucleotide-binding domain	0.46	2	20.30	382	405
AAA_23	AAA domain	0.0084	8	27.00	382	403
AAA_24	AAA domain	0.003	9	27.00	383	417
APS_kinase	Adenylylsulphate kinase	0.016	7	20.70	383	405
KAP_NTPase	KAP family P-loop domain	0.013	6	20.00	383	490
P-loop_TraG	TraG P-loop domain	0.023	5	25.80	384	417
AAA_10	AAA-like domain	0.0083	7	27.50	384	431
DUF815	Protein of unknown function (DUF815)	0.0016	9	20.10	384	468
AAA_30	AAA domain	0.0005	11	27.00	384	415
AAA_16	AAA ATPase domain	3.3E-05	16	32.60	384	539
Zeta_toxin	Zeta toxin	1.8E-05	16	20.10	385	424
AAA_15	AAA ATPase domain	0.00018	13	32.10	385	469
Ploopntkinase3	P-loop Nucleotide Kinase3	0.0039	8	27.00	385	410
NACHT	NACHT domain	0.034	6	20.40	385	400
NB-ARC	NB-ARC domain	0.028	5	23.50	385	403
SRP54	SRP54-type protein, GTPase domain	0.014	7	20.50	385	431
AAA_33	AAA domain	0.027	6	27.00	386	401
NTPase_1	NTPase	0.17	3	23.90	386	403
Roc	Ras of Complex, Roc, domain of DAPkinase	0.073	5	27.00	386	406
Dynamin_N	Dynamin family	0.052	5	21.00	386	401
AAA_18	AAA domain	0.0068	9	29.40	386	424
PRK	Phosphoribulokinase / Uridine kinase family	0.017	6	20.60	386	407
Gtr1_RagA	Gtr1/RagA G protein conserved region	0.0044	8	20.10	386	428
AAA_5	AAA domain (dynein-related subfamily)	0.0028	9	20.80	386	431
MMR_HSR1	GTPase of unknown function	0.0096	8	24.50	386	403
G-alpha	G-protein alpha subunit	0.00022	12	20.10	386	410
DUF87	Domain of unknown function DUF87	0.0009	11	20.90	386	417
AAA_22	AAA domain	4.1E-05	16	27.00	386	535
SMC_N	RecF/RecN/SMC N terminal domain	8.4E-07	20	40.00	387	566
AAA_21	AAA domain, putative AbiEii toxin, Type IV TA system	0.00061	11	27.00	387	430
RNA_helicase	RNA helicase	0.15	4	21.50	387	402
AAA	ATPase family associated with various cellular activities (AAA)	0.00068	12	20.80	388	546
AAA_17	AAA domain	0.042	6	27.00	389	419
ABC_ATPase	Predicted ATPase of the ABC class	2.1E-06	18	19.30	464	524
SbcCD_C	Putative exonuclease SbcCD, C subunit	0.0043	9	27.00	493	535
ABC_membrane	ABC transporter transmembrane region	0	156	22.00	687	943
ABC_tran	ABC transporter	2.9E-37	120	23.10	1013	1161
ATP-synt_ab	ATP synthase alpha/beta family, nucleotide-binding domain	0.0012	10	20.30	1013	1187
TsaE	Threonylcarbamoyl adenosine biosynthesis protein TsaE	0.043	5	26.60	1014	1043
AAA_29	P-loop containing region of AAA domain	2.1E-05	16	27.00	1016	1038
AAA_7	P-loop containing dynein motor region	0.0021	9	25.80	1017	1046
DEAD	DEAD/DEAH box helicase	0.00023	13	20.60	1017	1178
Sigma54_activat	Sigma-54 interaction domain	0.014	7	20.20	1017	1046
AAA_25	AAA domain	0.0067	8	27.00	1018	1038
DLIC	Dynein light intermediate chain (DLIC)	0.00072	10	19.30	1018	1046
ATPase	KaiC	0.019	6	26.60	1018	1037
TruB_C	tRNA Pseudouridine synthase II, C terminal	0.057	5	21.60	1019	1037
AAA_16	AAA ATPase domain	2.1E-05	17	32.60	1019	1070
RsgA_GTPase	RsgA GTPase	0.00032	12	30.00	1020	1042
AAA_30	AAA domain	0.0009	11	27.00	1020	1174
AAA_23	AAA domain	0.0085	8	27.00	1020	1041
AAA_24	AAA domain	0.0031	9	27.00	1021	1043
APS_kinase	Adenylylsulphate kinase	0.017	7	20.70	1021	1044
KAP_NTPase	KAP family P-loop domain	0.067	4	20.00	1021	1075
P-loop_TraG	TraG P-loop domain	0.012	6	25.80	1022	1055
DUF815	Protein of unknown function (DUF815)	0.0022	9	20.10	1022	1078
AAA_15	AAA ATPase domain	7.8E-05	14	32.10	1022	1061
Zeta_toxin	Zeta toxin	0.00084	10	20.10	1022	1060
SMC_N	RecF/RecN/SMC N terminal domain	0.026	6	40.00	1022	1041
SRP54	SRP54-type protein, GTPase domain	0.067	4	20.50	1023	1054
NB-ARC	NB-ARC domain	0.031	5	23.50	1023	1041
NACHT	NACHT domain	0.022	6	20.40	1023	1039
AAA_10	AAA-like domain	0.11	3	27.50	1024	1053
AAA_33	AAA domain	0.053	5	27.00	1024	1038
Dynamin_N	Dynamin family	0.048	5	21.00	1024	1041
Roc	Ras of Complex, Roc, domain of DAPkinase	0.057	5	27.00	1024	1040
NTPase_1	NTPase	0.096	4	23.90	1024	1041
AAA_22	AAA domain	0.00036	13	27.00	1024	1047
G-alpha	G-protein alpha subunit	0.00022	12	20.10	1024	1054
DUF87	Domain of unknown function DUF87	0.0016	10	20.90	1024	1054
AAA_5	AAA domain (dynein-related subfamily)	0.01	7	20.80	1024	1046
MMR_HSR1	GTPase of unknown function	0.009	8	24.50	1024	1041
AAA_18	AAA domain	0.073	5	29.40	1024	1042
Ploopntkinase3	P-loop Nucleotide Kinase3	0.029	6	27.00	1024	1045
Gtr1_RagA	Gtr1/RagA G protein conserved region	0.048	5	20.10	1024	1052
PRK	Phosphoribulokinase / Uridine kinase family	0.0095	7	20.60	1024	1046
AAA_21	AAA domain, putative AbiEii toxin, Type IV TA system	0.015	7	27.00	1025	1045
RNA_helicase	RNA helicase	0.094	5	21.50	1025	1040
AAA	ATPase family associated with various cellular activities (AAA)	0.014	7	20.80	1026	1184
AAA_17	AAA domain	0.18	4	27.00	1027	1046
SMC_N	RecF/RecN/SMC N terminal domain	1.7E-06	19	40.00	1082	1204
ABC_ATPase	Predicted ATPase of the ABC class	1.7E-05	15	19.30	1108	1163
SbcCD_C	Putative exonuclease SbcCD, C subunit	0.0057	9	27.00	1149	1175