c2pfam

AT4G37760.1 :

Domain Description Evalue Bits GA Start End
Shikimate_DH Shikimate / quinate 5-dehydrogenase 0.0002 12 24.30 53 98
AlaDh_PNT_C Alanine dehydrogenase/PNT, C-terminal domain 0.00064 9 20.30 53 88
Thi4 Thi4 family 1.8E-06 18 20.00 54 88
FAD_binding_3 FAD binding domain 3.2E-19 60 20.10 54 370
DAO FAD dependent oxidoreductase 3.7E-08 24 24.70 56 86
FAD_binding_2 FAD binding domain 2.9E-07 20 20.40 56 85
Pyr_redox_2 Pyridine nucleotide-disulphide oxidoreductase 4E-07 20 22.80 56 86
Lycopene_cycl Lycopene cyclase protein 4.6E-06 16 23.40 56 84
HI0933_like HI0933-like protein 8.2E-06 15 20.30 56 85
FAD_oxidored FAD dependent oxidoreductase 6.7E-05 13 27.00 56 86
Trp_halogenase Tryptophan halogenase 0.0043 6 19.60 56 87
GIDA Glucose inhibited division protein A 1.9E-06 17 20.00 56 218
ApbA Ketopantoate reductase PanE/ApbA 7.1E-05 13 21.70 57 86
TrkA_N TrkA-N domain 8.4E-05 13 21.70 57 87
NAD_Gly3P_dh_N NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.00017 12 23.10 57 91
Pyr_redox Pyridine nucleotide-disulphide oxidoreductase 1.5E-05 16 22.00 57 85
Pyr_redox_3 Pyridine nucleotide-disulphide oxidoreductase 0.00026 11 30.00 58 86
NAD_binding_8 NAD(P)-binding Rossmann-like domain 3.6E-08 24 21.90 59 85
DAO FAD dependent oxidoreductase 7.6E-05 13 24.70 152 237
Trp_halogenase Tryptophan halogenase 0.088 2 19.60 153 219
Pyr_redox_2 Pyridine nucleotide-disulphide oxidoreductase 0.98 -1 22.80 171 203
FAD_binding_2 FAD binding domain 0.13 2 20.40 172 225
SE Squalene epoxidase 0 395 20.10 205 475

525

Shikimate_DH
AlaDh_PNT_C
Thi4
FAD_binding_3
DAO
FAD_binding_2
Pyr_redox_2
Lycopene_cycl
HI0933_like
FAD_oxidored
Trp_halogenase
GIDA
ApbA
TrkA_N
NAD_Gly3P_dh_N
Pyr_redox
Pyr_redox_3
NAD_binding_8
DAO
Trp_halogenase
Pyr_redox_2
FAD_binding_2
SE

References:

TrkA_N
9478130 A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease. Trends Biochem Sci 1998;23:17-19.
8412700 NAD+ binding to the Escherichia coli K(+)-uptake protein TrkA and sequence similarity between TrkA and domains of a family of dehydrogenases suggest a role for NAD+ in bacterial transport. Mol Microbiol 1993;9:533-543.
11292341 Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. J Mol Biol 2001;307:1271-1292.

Shikimate_DH
7556173 The molecular biology of multidomain proteins. Selected examples. Eur J Biochem 1995;232:7-18.

FAD_binding_2
8061609 Structure of glutathione reductase from Escherichia coli at 1.86 A resolution: comparison with the enzyme from human erythrocytes. Protein Sci 1994;3:799-809.

Lycopene_cycl
8837512 Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation. Plant Cell 1996;8:1613-1626.
11226339 One ring or two? Determination of ring number in carotenoids by lycopene epsilon-cyclases. Proc Natl Acad Sci U S A 2001;98:2905-2910.

ApbA
9488683 ApbA, the ketopantoate reductase enzyme of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway. J Biol Chem 1998;273:5572-5576.
9721324 The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium. J Bacteriol 1998;180:4757-4759.

Thi4
7961415 Cloning, nucleotide sequence, and regulation of Schizosaccharomyces pombe thi4, a thiamine biosynthetic gene. J Bacteriol 1994;176:6631-6635.

FAD_binding_3
1409567 Crystal structure of the reduced form of p-hydroxybenzoate hydroxylase refined at 2.3A resolution. Proteins 1992;14:178-190.

Pyr_redox_2
8805537 Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. Structure 1996;4:277-286.

DAO
9153426 Active site plasticity in D-amino acid oxidase: a crystallographic analysis. Biochemistry 1997;36:5853-5860.

HI0933_like

SE
9161422 Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans. Gene 1997;189:119-126.

Pyr_redox
8805537 Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. Structure 1996;4:277-286.

GIDA

Pyr_redox_3

FAD_oxidored

AlaDh_PNT_C
11354603 Lysine metabolism in higher plants. Amino Acids 2001;20:261-279.

Trp_halogenase
10547442 Conservation of the pyrrolnitrin biosynthetic gene cluster among six pyrrolnitrin-producing strains. FEMS Microbiol Lett 1999;180:39-44.

NAD_binding_8

NAD_Gly3P_dh_N
12032156 Kinetic regulation of the mitochondrial glycerol-3-phosphate dehydrogenase by the external NADH dehydrogenase in Saccharomyces cerevisiae. J Biol Chem 2002;277:27991-27995.
10801498 A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana. Structure Fold Des 2000;8:541-552.

Domain	Description	Evalue	Bits	GA	Start	End
Shikimate_DH	Shikimate / quinate 5-dehydrogenase	0.0002	12	24.30	53	98
AlaDh_PNT_C	Alanine dehydrogenase/PNT, C-terminal domain	0.00064	9	20.30	53	88
Thi4	Thi4 family	1.8E-06	18	20.00	54	88
FAD_binding_3	FAD binding domain	3.2E-19	60	20.10	54	370
DAO	FAD dependent oxidoreductase	3.7E-08	24	24.70	56	86
FAD_binding_2	FAD binding domain	2.9E-07	20	20.40	56	85
Pyr_redox_2	Pyridine nucleotide-disulphide oxidoreductase	4E-07	20	22.80	56	86
Lycopene_cycl	Lycopene cyclase protein	4.6E-06	16	23.40	56	84
HI0933_like	HI0933-like protein	8.2E-06	15	20.30	56	85
FAD_oxidored	FAD dependent oxidoreductase	6.7E-05	13	27.00	56	86
Trp_halogenase	Tryptophan halogenase	0.0043	6	19.60	56	87
GIDA	Glucose inhibited division protein A	1.9E-06	17	20.00	56	218
ApbA	Ketopantoate reductase PanE/ApbA	7.1E-05	13	21.70	57	86
TrkA_N	TrkA-N domain	8.4E-05	13	21.70	57	87
NAD_Gly3P_dh_N	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus	0.00017	12	23.10	57	91
Pyr_redox	Pyridine nucleotide-disulphide oxidoreductase	1.5E-05	16	22.00	57	85
Pyr_redox_3	Pyridine nucleotide-disulphide oxidoreductase	0.00026	11	30.00	58	86
NAD_binding_8	NAD(P)-binding Rossmann-like domain	3.6E-08	24	21.90	59	85
DAO	FAD dependent oxidoreductase	7.6E-05	13	24.70	152	237
Trp_halogenase	Tryptophan halogenase	0.088	2	19.60	153	219
Pyr_redox_2	Pyridine nucleotide-disulphide oxidoreductase	0.98	-1	22.80	171	203
FAD_binding_2	FAD binding domain	0.13	2	20.40	172	225
SE	Squalene epoxidase	0	395	20.10	205	475