c2pfam

AT5G11250.1 :

Domain Description Evalue Bits GA Start End
TIR TIR domain 0 140 21.20 4 156
TIR_2 TIR domain 5.4E-12 37 28.00 4 75
AAA_16 AAA ATPase domain 3.1E-06 18 32.60 154 213
NB-ARC NB-ARC domain 3.3E-22 69 23.50 160 397
Rad17 Rad17 cell cycle checkpoint protein 3.5E-06 17 19.70 170 269
ATPase_2 ATPase domain predominantly from Archaea 8E-06 16 33.20 170 244
ABC_tran ABC transporter 0.00012 13 23.10 174 201
AAA_22 AAA domain 6.4E-05 14 27.00 176 210
AAA_14 AAA domain 7.7E-05 13 27.00 176 294
NACHT NACHT domain 0.00055 10 20.40 177 275
AAA_24 AAA domain 9E-05 13 27.00 178 198
NTPase_1 NTPase 0.00014 12 23.90 178 203
AAA_18 AAA domain 3.2E-06 18 29.40 178 302
RNA_helicase RNA helicase 0.00021 12 21.50 180 220
RuvB_N Holliday junction DNA helicase ruvB N-terminus 3.3E-05 14 20.00 180 204
AAA ATPase family associated with various cellular activities (AAA) 6.4E-07 20 20.80 180 203
LRR_3 Leucine Rich Repeat 5.2E-09 26 20.20 572 591
NACHT NACHT domain 0.19 2 20.40 596 635
LRR_5 BspA type Leucine rich repeat region (6 copies) 0.8 0 27.70 624 677
LRR_5 BspA type Leucine rich repeat region (6 copies) 1.4E-05 15 27.70 783 847

1107

TIR
TIR_2
AAA_16
NB-ARC
Rad17
ATPase_2
ABC_tran
AAA_22
AAA_14
NACHT
AAA_24
NTPase_1
AAA_18
RNA_helicase
RuvB_N
AAA
LRR_3
NACHT
LRR_5
LRR_5

References:

AAA_16

AAA_14

ABC_tran
1864505 Homology between proteins controlling Streptomyces fradiae tylosin resistance and ATP-binding transport. Gene 1991;102:27-32.
1977073 Structure and function of haemolysin B,P-glycoprotein and other members of a novel family of membrane translocators. Mol Microbiol 1990;4:873-880.
2229036 Binding protein-dependent transport systems. J Bioenerg Biomembr 1990;22:571-592.
9872322 Crystal structure of the ATP-binding subunit of an ABC transporter. Nature 1998;396:703-707.

AAA
7646486 A 200-amino acid ATPase module in search of a basic function. Bioessays 1995;17:639-650.
9927482 AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res 1999;9:27-43.

LRR_3
7817399 The leucine-rich repeat: a versatile binding motif. Trends Biochem Sci 1994;19:415-421.
8264799 Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature 1993;366:751-756.

NB-ARC
9545207 The NB-ARC domain: a novel signalling motif shared by plant resistance gene products and regulators of cell death in animals. Curr Biol 1998;8:226-227.

RuvB_N
12423347 The RuvABC resolvasome. Eur J Biochem 2002;269:5492-5501.

LRR_5

NTPase_1

ATPase_2

NACHT
10782090 The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation. Trends Biochem Sci 2000;25:223-224.

Rad17
10208430 hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation. Oncogene 1999;18:1689-1699.

TIR_2

RNA_helicase
2546125 Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res 1989;17:4713-4730.

AAA_24

TIR
9013863 The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. FEBS Lett 1997;402:81-84.
9237759 A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [see comments] Nature 1997;388:394-397.
12186654 Toll-like receptors: a family of pattern-recognition receptors in mammals. Genome Biol 2002;3:REVIEWS3011.

AAA_22

AAA_18

Domain	Description	Evalue	Bits	GA	Start	End
TIR	TIR domain	0	140	21.20	4	156
TIR_2	TIR domain	5.4E-12	37	28.00	4	75
AAA_16	AAA ATPase domain	3.1E-06	18	32.60	154	213
NB-ARC	NB-ARC domain	3.3E-22	69	23.50	160	397
Rad17	Rad17 cell cycle checkpoint protein	3.5E-06	17	19.70	170	269
ATPase_2	ATPase domain predominantly from Archaea	8E-06	16	33.20	170	244
ABC_tran	ABC transporter	0.00012	13	23.10	174	201
AAA_22	AAA domain	6.4E-05	14	27.00	176	210
AAA_14	AAA domain	7.7E-05	13	27.00	176	294
NACHT	NACHT domain	0.00055	10	20.40	177	275
AAA_24	AAA domain	9E-05	13	27.00	178	198
NTPase_1	NTPase	0.00014	12	23.90	178	203
AAA_18	AAA domain	3.2E-06	18	29.40	178	302
RNA_helicase	RNA helicase	0.00021	12	21.50	180	220
RuvB_N	Holliday junction DNA helicase ruvB N-terminus	3.3E-05	14	20.00	180	204
AAA	ATPase family associated with various cellular activities (AAA)	6.4E-07	20	20.80	180	203
LRR_3	Leucine Rich Repeat	5.2E-09	26	20.20	572	591
NACHT	NACHT domain	0.19	2	20.40	596	635
LRR_5	BspA type Leucine rich repeat region (6 copies)	0.8	0	27.70	624	677
LRR_5	BspA type Leucine rich repeat region (6 copies)	1.4E-05	15	27.70	783	847