c2pfam

AT5G19330.1 :

Domain Description Evalue Bits GA Start End
DUF3361 Domain of unknown function (DUF3361) 0.17 2 27.20 64 107
V-ATPase_H_N V-ATPase subunit H 0.19 1 20.10 74 114
Arm Armadillo/beta-catenin-like repeat 0.044 4 20.60 88 106
HEAT_EZ HEAT-like repeat 0.29 2 27.00 127 159
Arm Armadillo/beta-catenin-like repeat 1.6E-06 18 20.60 138 184
V-ATPase_H_N V-ATPase subunit H 0.00021 10 20.10 138 252
HEAT_2 HEAT repeats 0.64 0 27.70 141 162
Adaptin_N Adaptin N terminal region 0.003 6 20.30 151 238
DUF3361 Domain of unknown function (DUF3361) 0.00079 9 27.20 168 235
HEAT_2 HEAT repeats 1.2E-05 15 27.70 172 225
HEAT_EZ HEAT-like repeat 5.2E-06 17 27.00 174 224
Atx10homo_assoc Spinocerebellar ataxia type 10 protein domain 1.1E-05 15 22.40 179 240
Arm_2 Armadillo-like 0.074 2 20.40 191 230
Arm Armadillo/beta-catenin-like repeat 3.2E-10 30 20.60 194 226
HEAT_2 HEAT repeats 2.5E-05 14 27.70 200 267
HEAT HEAT repeat 0.013 6 23.50 200 226
Adaptin_N Adaptin N terminal region 2.2E-05 13 20.30 208 315
HEAT_PBS PBS lyase HEAT-like repeat 0.12 3 20.90 214 225
Arm Armadillo/beta-catenin-like repeat 9.7E-10 28 20.60 229 268
HEAT_EZ HEAT-like repeat 0.5 1 27.00 241 267
HEAT HEAT repeat 0.041 4 23.50 242 268
HEAT_2 HEAT repeats 0.0054 7 27.70 243 312
DUF3361 Domain of unknown function (DUF3361) 0.031 4 27.20 251 306
Atx10homo_assoc Spinocerebellar ataxia type 10 protein domain 0.0041 7 22.40 259 288
UNC45-central Myosin-binding striated muscle assembly central 0.035 4 24.50 267 348
Arm Armadillo/beta-catenin-like repeat 0.00011 12 20.60 271 307
HEAT HEAT repeat 0.0078 7 23.50 284 311
HEAT_EZ HEAT-like repeat 0.2 2 27.00 286 304
HEAT_EZ HEAT-like repeat 6.4E-05 13 27.00 299 351
HEAT_PBS PBS lyase HEAT-like repeat 0.3 2 20.90 299 334
Arm Armadillo/beta-catenin-like repeat 3.4E-08 23 20.60 313 352
V-ATPase_H_N V-ATPase subunit H 2.4E-05 13 20.10 325 495
HEAT HEAT repeat 0.00014 12 23.50 327 353
HEAT_2 HEAT repeats 0.00019 12 27.70 327 395
Arm_2 Armadillo-like 0.0031 7 20.40 327 400
Atx10homo_assoc Spinocerebellar ataxia type 10 protein domain 0.17 2 22.40 354 405
Arm Armadillo/beta-catenin-like repeat 7.6E-06 16 20.60 361 391
HEAT_EZ HEAT-like repeat 0.44 1 27.00 367 389
HEAT HEAT repeat 0.11 3 23.50 369 394
Adaptin_N Adaptin N terminal region 0.044 2 20.30 370 398
HEAT_PBS PBS lyase HEAT-like repeat 0.19 3 20.90 382 394
UNC45-central Myosin-binding striated muscle assembly central 0.00042 10 24.50 439 506
HEAT_2 HEAT repeats 0.38 1 27.70 439 470
Arm Armadillo/beta-catenin-like repeat 0.0043 7 20.60 440 468
HEAT_PBS PBS lyase HEAT-like repeat 0.74 1 20.90 456 470
Arm Armadillo/beta-catenin-like repeat 0.021 5 20.60 471 498
BTB BTB/POZ domain 2.9E-29 91 20.50 534 636
BTB BTB/POZ domain 0.75 0 20.50 632 668

710

DUF3361
V-ATPase_H_N
Arm
HEAT_EZ
Arm
V-ATPase_H_N
HEAT_2
Adaptin_N
DUF3361
HEAT_2
HEAT_EZ
Atx10homo_assoc
Arm_2
Arm
HEAT_2
HEAT
Adaptin_N
HEAT_PBS
Arm
HEAT_EZ
HEAT
HEAT_2
DUF3361
Atx10homo_assoc
UNC45-central
Arm
HEAT
HEAT_EZ
HEAT_EZ
HEAT_PBS
Arm
V-ATPase_H_N
HEAT
HEAT_2
Arm_2
Atx10homo_assoc
Arm
HEAT_EZ
HEAT
Adaptin_N
HEAT_PBS
UNC45-central
HEAT_2
Arm
HEAT_PBS
Arm
BTB
BTB

References:

V-ATPase_H_N
10954728 Regulation of yeast ectoapyrase ynd1p activity by activator subunit Vma13p of vacuolar H+-ATPase. J Biol Chem 2000;275:35592-35599.
18708638 Functional characterization of the N-terminal domain of subunit H (Vma13p) of the yeast vacuolar ATPase. J Biol Chem. 2008; [Epub ahead of print]
16141210 Structural and functional separation of the N- and C-terminal domains of the yeast V-ATPase subunit H. J Biol Chem. 2005;280:36978-36985.

DUF3361

Arm
9298899 Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell 1997;90:871-882.
8573337 Signal transduction of beta-catenin. Curr Opin Cell Biol 1995;7:634-640.
9309175 Armadillo and dTCF: a marriage made in the nucleus. Curr Opin Genet Dev 1997;7:459-466.
8259519 Association of the APC tumor suppressor protein with catenins. Science 1993;262:1734-1737.
8259518 Association of the APC gene product with beta-catenin. Science 1993;262:1731-1734.
2261639 The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell 1990;63:1167-1176.

Adaptin_N
9261055 Linking cargo to vesicle formation: receptor tail interactions with coat proteins. Curr Opin Cell Biol 1997;9:488-495.
2495531 Structural and functional division into two domains of the large (100- to 115-kDa)chains of the clathrin-associated protein complex AP-2. Proc Natl Acad Sci U S A 1989;86:2612-2616.

Atx10homo_assoc
15201271 Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons. J Biol Chem. 2004;279:35542-35550.

HEAT_PBS
8132596 Oligomeric structure, enzyme kinetics, and substrate specificity of the phycocyanin alpha subunit phycocyanobilin lyase. J Biol Chem 1994;269:8686-8694.
9023176 A role for cpeYZ in cyanobacterial phycoerythrin biosynthesis. J Bacteriol 1997;179:998-1006.
10708746 Novel activity of a phycobiliprotein lyase: both the attachment of phycocyanobilin and the isomerization to phycoviolobilin are catalyzed by the proteins PecE and PecF encoded by the phycoerythrocyanin operon. FEBS Lett 2000;469:9-13.
9882677 A polypeptide with similarity to phycocyanin alpha-subunit phycocyanobilin lyase involved in degradation of phycobilisomes. J Bacteriol 1999;181:610-617.

HEAT
7550332 HEAT repeats in the Huntington's disease protein. Nat Genet 1995;11:115-116.
9989501 The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell 1999;96:99-110.

HEAT_EZ

HEAT_2

BTB
7938017 The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc Natl Acad Sci U S A 1994;91:10717-10721.
7958847 The POZ domain: a conserved protein-protein interaction motif. Genes Dev 1994;8:1664-1677.
9770450 Crystal structure of the BTB domain from PLZF. Proc Natl Acad Sci U S A 1998;95:12123-12128.
9019154 The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ 1995;6:1495-1503.
9824158 The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Oncogene 1998;17:2473-2484.
9765306 Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. J Biol Chem 1998;273:27695-27702.
16207353 Sequence and structural analysis of BTB domain proteins. Genome Biol. 2005;6:R82.

Arm_2

UNC45-central
12356907 Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. J Cell Sci. 2002;115:4013-4023.
18523008 Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells. Proc Natl Acad Sci U S A. 2008;105:8014-8019.
18478096 Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain. PLoS ONE. 2008;3:e2137.

Domain	Description	Evalue	Bits	GA	Start	End
DUF3361	Domain of unknown function (DUF3361)	0.17	2	27.20	64	107
V-ATPase_H_N	V-ATPase subunit H	0.19	1	20.10	74	114
Arm	Armadillo/beta-catenin-like repeat	0.044	4	20.60	88	106
HEAT_EZ	HEAT-like repeat	0.29	2	27.00	127	159
Arm	Armadillo/beta-catenin-like repeat	1.6E-06	18	20.60	138	184
V-ATPase_H_N	V-ATPase subunit H	0.00021	10	20.10	138	252
HEAT_2	HEAT repeats	0.64	0	27.70	141	162
Adaptin_N	Adaptin N terminal region	0.003	6	20.30	151	238
DUF3361	Domain of unknown function (DUF3361)	0.00079	9	27.20	168	235
HEAT_2	HEAT repeats	1.2E-05	15	27.70	172	225
HEAT_EZ	HEAT-like repeat	5.2E-06	17	27.00	174	224
Atx10homo_assoc	Spinocerebellar ataxia type 10 protein domain	1.1E-05	15	22.40	179	240
Arm_2	Armadillo-like	0.074	2	20.40	191	230
Arm	Armadillo/beta-catenin-like repeat	3.2E-10	30	20.60	194	226
HEAT_2	HEAT repeats	2.5E-05	14	27.70	200	267
HEAT	HEAT repeat	0.013	6	23.50	200	226
Adaptin_N	Adaptin N terminal region	2.2E-05	13	20.30	208	315
HEAT_PBS	PBS lyase HEAT-like repeat	0.12	3	20.90	214	225
Arm	Armadillo/beta-catenin-like repeat	9.7E-10	28	20.60	229	268
HEAT_EZ	HEAT-like repeat	0.5	1	27.00	241	267
HEAT	HEAT repeat	0.041	4	23.50	242	268
HEAT_2	HEAT repeats	0.0054	7	27.70	243	312
DUF3361	Domain of unknown function (DUF3361)	0.031	4	27.20	251	306
Atx10homo_assoc	Spinocerebellar ataxia type 10 protein domain	0.0041	7	22.40	259	288
UNC45-central	Myosin-binding striated muscle assembly central	0.035	4	24.50	267	348
Arm	Armadillo/beta-catenin-like repeat	0.00011	12	20.60	271	307
HEAT	HEAT repeat	0.0078	7	23.50	284	311
HEAT_EZ	HEAT-like repeat	0.2	2	27.00	286	304
HEAT_EZ	HEAT-like repeat	6.4E-05	13	27.00	299	351
HEAT_PBS	PBS lyase HEAT-like repeat	0.3	2	20.90	299	334
Arm	Armadillo/beta-catenin-like repeat	3.4E-08	23	20.60	313	352
V-ATPase_H_N	V-ATPase subunit H	2.4E-05	13	20.10	325	495
HEAT	HEAT repeat	0.00014	12	23.50	327	353
HEAT_2	HEAT repeats	0.00019	12	27.70	327	395
Arm_2	Armadillo-like	0.0031	7	20.40	327	400
Atx10homo_assoc	Spinocerebellar ataxia type 10 protein domain	0.17	2	22.40	354	405
Arm	Armadillo/beta-catenin-like repeat	7.6E-06	16	20.60	361	391
HEAT_EZ	HEAT-like repeat	0.44	1	27.00	367	389
HEAT	HEAT repeat	0.11	3	23.50	369	394
Adaptin_N	Adaptin N terminal region	0.044	2	20.30	370	398
HEAT_PBS	PBS lyase HEAT-like repeat	0.19	3	20.90	382	394
UNC45-central	Myosin-binding striated muscle assembly central	0.00042	10	24.50	439	506
HEAT_2	HEAT repeats	0.38	1	27.70	439	470
Arm	Armadillo/beta-catenin-like repeat	0.0043	7	20.60	440	468
HEAT_PBS	PBS lyase HEAT-like repeat	0.74	1	20.90	456	470
Arm	Armadillo/beta-catenin-like repeat	0.021	5	20.60	471	498
BTB	BTB/POZ domain	2.9E-29	91	20.50	534	636
BTB	BTB/POZ domain	0.75	0	20.50	632	668