c2pfam

AT5G23580.1 :

Domain Description Evalue Bits GA Start End
Kinase-like Kinase-like 0.04 4 25.00 21 63
Pkinase Protein kinase domain 0 254 20.40 25 280
PK_Tyr_Ser-Thr Protein tyrosine and serine/threonine kinase 2.4E-30 96 23.10 25 274
Haspin_kinase Haspin like kinase domain 0.00065 9 25.00 28 78
APH Phosphotransferase enzyme family 0.33 1 22.40 36 138
DUF2004 Protein of unknown function (DUF2004) 0.0012 10 21.60 53 111
RIO1 RIO1 family 0.00015 12 20.40 69 156
Haspin_kinase Haspin like kinase domain 0.49 0 25.00 93 159
Kdo Lipopolysaccharide kinase (Kdo/WaaP) family 6.5E-07 20 20.90 94 162
Kinase-like Kinase-like 3.4E-06 17 25.00 115 268
APH Phosphotransferase enzyme family 0.0011 9 22.40 138 158
EF-hand_8 EF-hand domain pair 4.2E-07 20 28.00 310 353
EF-hand_4 Cytoskeletal-regulatory complex EF hand 4.9E-05 14 21.30 319 387
EF-hand_4 Cytoskeletal-regulatory complex EF hand 0.017 6 21.30 326 354
EF-hand_7 EF-hand domain pair 1.1E-14 45 30.00 328 388
EF-hand_5 EF hand 6.3E-09 26 25.90 328 349
EF-hand_6 EF-hand domain 1.3E-09 28 25.00 328 353
EF-hand_1 EF hand 1E-10 31 25.40 328 354
EF-hand_9 EF-hand domain 1.5E-07 22 37.00 330 386
EFhand_Ca_insen Ca2+ insensitive EF hand 0.2 3 20.80 330 387
EF-hand_10 EF hand 0.054 4 27.00 330 350
EF-hand_14 EF-hand domain 0.18 3 23.70 331 370
SPARC_Ca_bdg Secreted protein acidic and rich in cysteine Ca binding region 0.0018 9 21.40 332 385
Caleosin Caleosin related protein 0.07 4 20.60 334 364
Sigma70_r1_1 Sigma-70 factor, region 1.1 0.014 6 20.80 339 373
PMBR Pseudomurein-binding repeat 0.0028 9 24.90 340 358
EF-hand_8 EF-hand domain pair 1.5E-12 38 28.00 340 387
EF-hand_10 EF hand 0.013 6 27.00 343 384
EF-hand_1 EF hand 8.7E-07 19 25.40 363 387
EF-hand_6 EF-hand domain 0.00068 10 25.00 363 387
EF-hand_5 EF hand 0.00012 12 25.90 364 384
Herpes_UL36 Herpesvirus UL36 tegument protein 0.0009 9 20.50 365 419
EFhand_Ca_insen Ca2+ insensitive EF hand 0.0017 9 20.80 397 457
SPARC_Ca_bdg Secreted protein acidic and rich in cysteine Ca binding region 0.00025 12 21.40 398 455
EF-hand_8 EF-hand domain pair 0.003 8 28.00 398 424
EF-hand_7 EF-hand domain pair 7.5E-13 40 30.00 399 459
EF-hand_5 EF hand 1.8E-07 21 25.90 400 422
EF-hand_6 EF-hand domain 1.3E-08 25 25.00 400 425
EF-hand_1 EF hand 9.2E-09 25 25.40 402 426
EF-hand_9 EF-hand domain 9.8E-06 17 37.00 403 460
Caleosin Caleosin related protein 0.0061 7 20.60 404 430
EF-hand_14 EF-hand domain 0.01 7 23.70 404 446
EF-hand_4 Cytoskeletal-regulatory complex EF hand 2.4E-05 15 21.30 410 459
EF-hand_8 EF-hand domain pair 1.9E-11 34 28.00 412 460
Sigma70_r1_1 Sigma-70 factor, region 1.1 0.046 5 20.80 412 442
EF-hand_10 EF hand 0.5 1 27.00 429 457
Caleosin Caleosin related protein 0.25 2 20.60 432 460
EF-hand_1 EF hand 5.5E-11 32 25.40 434 460
EF-hand_5 EF hand 3.9E-05 14 25.90 435 458
EF-hand_6 EF-hand domain 7.8E-07 19 25.00 436 460
Herpes_UL36 Herpesvirus UL36 tegument protein 0.84 -1 20.50 436 457

490

Kinase-like
Pkinase
PK_Tyr_Ser-Thr
Haspin_kinase
APH
DUF2004
RIO1
Haspin_kinase
Kdo
Kinase-like
APH
EF-hand_8
EF-hand_4
EF-hand_4
EF-hand_7
EF-hand_5
EF-hand_6
EF-hand_1
EF-hand_9
EFhand_Ca_insen
EF-hand_10
EF-hand_14
SPARC_Ca_bdg
Caleosin
Sigma70_r1_1
PMBR
EF-hand_8
EF-hand_10
EF-hand_1
EF-hand_6
EF-hand_5
Herpes_UL36
EFhand_Ca_insen
SPARC_Ca_bdg
EF-hand_8
EF-hand_7
EF-hand_5
EF-hand_6
EF-hand_1
EF-hand_9
Caleosin
EF-hand_14
EF-hand_4
EF-hand_8
Sigma70_r1_1
EF-hand_10
Caleosin
EF-hand_1
EF-hand_5
EF-hand_6
Herpes_UL36

References:

APH
2163618 Cloning of aminoglycoside phosphotransferase (APH) gene from antibiotic- producing strain of Bacillus circulans into a high-expression vector, pKK223-3. Purification, properties and location of the enzyme [published erratum appears in Biochem J 1991 Feb 1 Biochem J 1990;268:671-677.
2167474 PCR cloning of a streptomycin phosphotransferase (aphE) gene from Streptomyces griseus ATCC 12475. Nucleic Acids Res 1990;18:4615-4615.

Herpes_UL36
1331541 Analysis of the UL36 open reading frame encoding the large tegument protein (ICP1/2) of herpes simplex virus type 1. J Virol 1992;66:7581-7584.

SPARC_Ca_bdg
16121393 The C-terminal Ca2+-binding domain of SPARC confers anti-spreading activity to human urothelial cells. J Cell Physiol. 2006;206:211-220.

EF-hand_9

EF-hand_8

EF-hand_7

EF-hand_6

Kdo
11069912 Purification and characterization of WaaP from Escherichia coli, a lipopolysaccharide kinase essential for outer membrane stability. J Biol Chem 2001;276:5498-5504.
12021457 Lipopolysaccharide phosphorylating enzymes encoded in the genomes of Gram-negative bacteria are related to the eukaryotic protein kinases. Protein Sci 2002;11:1580-1584.
10531340 A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence. J Biol Chem 1999;274:31391-31400.

EF-hand_4

Sigma70_r1_1
9927430 A mutation in region 1.1 of sigma70 affects promoter DNA binding by Escherichia coli RNA polymerase holoenzyme. EMBO J 1999;18:709-716.
10613885 Effects of amino acid substitutions at conserved and acidic residues within region 1.1 of Escherichia coli sigma(70). J Bacteriol 2000;182:221-224.

EF-hand_14

PMBR

Haspin_kinase

EF-hand_10

EF-hand_1

RIO1
12021457 Lipopolysaccharide phosphorylating enzymes encoded in the genomes of Gram-negative bacteria are related to the eukaryotic protein kinases. Protein Sci 2002;11:1580-1584.
12612080 Late cytoplasmic maturation of the small ribosomal subunit requires RIO proteins in Saccharomyces cerevisiae. Mol Cell Biol 2003;23:2083-2095.
12690111 Rio2p: An evolutionarily conserved, low-abundant protein kinase essential for processing of 20S Pre-rRNA in Saccharomyces cerevisiae. 0;0:0-0.
16008568 Structure and activity of the atypical serine kinase Rio1. FEBS J 2005;272:3698-3713.

Pkinase
1956325 Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol 1991;200:38-62.
7768349 Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 1995;9:576-596.
9020587 The protein kinases of budding yeast: six score and more. Trends Biochem Sci 1997;22:18-22.

Kinase-like

EFhand_Ca_insen
11573089 Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex. Nat Struct Biol. 2001;8:853-857.

DUF2004
16374782 NMR structure of the conserved novel-fold protein TA0743 from Thermoplasma acidophilum. Proteins. 2006;62:819-821.

Caleosin
11171180 New insights into the mechanisms of lipid-body biogenesis in plants and other organisms. Biochem Soc Trans 2000;28:710-711.

PK_Tyr_Ser-Thr

EF-hand_5

Domain	Description	Evalue	Bits	GA	Start	End
Kinase-like	Kinase-like	0.04	4	25.00	21	63
Pkinase	Protein kinase domain	0	254	20.40	25	280
PK_Tyr_Ser-Thr	Protein tyrosine and serine/threonine kinase	2.4E-30	96	23.10	25	274
Haspin_kinase	Haspin like kinase domain	0.00065	9	25.00	28	78
APH	Phosphotransferase enzyme family	0.33	1	22.40	36	138
DUF2004	Protein of unknown function (DUF2004)	0.0012	10	21.60	53	111
RIO1	RIO1 family	0.00015	12	20.40	69	156
Haspin_kinase	Haspin like kinase domain	0.49	0	25.00	93	159
Kdo	Lipopolysaccharide kinase (Kdo/WaaP) family	6.5E-07	20	20.90	94	162
Kinase-like	Kinase-like	3.4E-06	17	25.00	115	268
APH	Phosphotransferase enzyme family	0.0011	9	22.40	138	158
EF-hand_8	EF-hand domain pair	4.2E-07	20	28.00	310	353
EF-hand_4	Cytoskeletal-regulatory complex EF hand	4.9E-05	14	21.30	319	387
EF-hand_4	Cytoskeletal-regulatory complex EF hand	0.017	6	21.30	326	354
EF-hand_7	EF-hand domain pair	1.1E-14	45	30.00	328	388
EF-hand_5	EF hand	6.3E-09	26	25.90	328	349
EF-hand_6	EF-hand domain	1.3E-09	28	25.00	328	353
EF-hand_1	EF hand	1E-10	31	25.40	328	354
EF-hand_9	EF-hand domain	1.5E-07	22	37.00	330	386
EFhand_Ca_insen	Ca2+ insensitive EF hand	0.2	3	20.80	330	387
EF-hand_10	EF hand	0.054	4	27.00	330	350
EF-hand_14	EF-hand domain	0.18	3	23.70	331	370
SPARC_Ca_bdg	Secreted protein acidic and rich in cysteine Ca binding region	0.0018	9	21.40	332	385
Caleosin	Caleosin related protein	0.07	4	20.60	334	364
Sigma70_r1_1	Sigma-70 factor, region 1.1	0.014	6	20.80	339	373
PMBR	Pseudomurein-binding repeat	0.0028	9	24.90	340	358
EF-hand_8	EF-hand domain pair	1.5E-12	38	28.00	340	387
EF-hand_10	EF hand	0.013	6	27.00	343	384
EF-hand_1	EF hand	8.7E-07	19	25.40	363	387
EF-hand_6	EF-hand domain	0.00068	10	25.00	363	387
EF-hand_5	EF hand	0.00012	12	25.90	364	384
Herpes_UL36	Herpesvirus UL36 tegument protein	0.0009	9	20.50	365	419
EFhand_Ca_insen	Ca2+ insensitive EF hand	0.0017	9	20.80	397	457
SPARC_Ca_bdg	Secreted protein acidic and rich in cysteine Ca binding region	0.00025	12	21.40	398	455
EF-hand_8	EF-hand domain pair	0.003	8	28.00	398	424
EF-hand_7	EF-hand domain pair	7.5E-13	40	30.00	399	459
EF-hand_5	EF hand	1.8E-07	21	25.90	400	422
EF-hand_6	EF-hand domain	1.3E-08	25	25.00	400	425
EF-hand_1	EF hand	9.2E-09	25	25.40	402	426
EF-hand_9	EF-hand domain	9.8E-06	17	37.00	403	460
Caleosin	Caleosin related protein	0.0061	7	20.60	404	430
EF-hand_14	EF-hand domain	0.01	7	23.70	404	446
EF-hand_4	Cytoskeletal-regulatory complex EF hand	2.4E-05	15	21.30	410	459
EF-hand_8	EF-hand domain pair	1.9E-11	34	28.00	412	460
Sigma70_r1_1	Sigma-70 factor, region 1.1	0.046	5	20.80	412	442
EF-hand_10	EF hand	0.5	1	27.00	429	457
Caleosin	Caleosin related protein	0.25	2	20.60	432	460
EF-hand_1	EF hand	5.5E-11	32	25.40	434	460
EF-hand_5	EF hand	3.9E-05	14	25.90	435	458
EF-hand_6	EF-hand domain	7.8E-07	19	25.00	436	460
Herpes_UL36	Herpesvirus UL36 tegument protein	0.84	-1	20.50	436	457