c2pfam

AT5G24150.1 :

Domain Description Evalue Bits GA Start End
DUF1188 Protein of unknown function (DUF1188) 0.0002 11 26.50 28 75
Thi4 Thi4 family 7.2E-07 19 20.00 45 78
FAD_binding_3 FAD binding domain 2.3E-19 60 20.10 46 362
Shikimate_DH Shikimate / quinate 5-dehydrogenase 0.00027 11 24.30 46 89
Lycopene_cycl Lycopene cyclase protein 0.00028 10 23.40 47 75
DAO FAD dependent oxidoreductase 1.9E-09 28 24.70 47 77
FAD_binding_2 FAD binding domain 1.5E-07 21 20.40 47 76
GIDA Glucose inhibited division protein A 1.8E-05 14 20.00 47 76
Pyr_redox_2 Pyridine nucleotide-disulphide oxidoreductase 4.8E-07 20 22.80 47 81
FAD_oxidored FAD dependent oxidoreductase 3.8E-06 17 27.00 47 77
HI0933_like HI0933-like protein 6.3E-05 12 20.30 47 77
Trp_halogenase Tryptophan halogenase 0.0052 6 19.60 47 77
3HCDH_N 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 7.4E-05 13 20.90 48 84
Pyr_redox Pyridine nucleotide-disulphide oxidoreductase 1.2E-05 16 22.00 48 77
ApbA Ketopantoate reductase PanE/ApbA 6.1E-05 13 21.70 48 77
TrkA_N TrkA-N domain 0.00021 12 21.70 48 85
NAD_Gly3P_dh_N NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.00031 11 23.10 48 82
NAD_binding_8 NAD(P)-binding Rossmann-like domain 5.2E-09 27 21.90 50 76
DAO FAD dependent oxidoreductase 2E-06 18 24.70 139 213
Trp_halogenase Tryptophan halogenase 0.019 4 19.60 144 212
GIDA Glucose inhibited division protein A 0.00034 10 20.00 149 211
FAD_binding_2 FAD binding domain 0.016 5 20.40 151 213
SE Squalene epoxidase 0 374 20.10 199 472

516

DUF1188
Thi4
FAD_binding_3
Shikimate_DH
Lycopene_cycl
DAO
FAD_binding_2
GIDA
Pyr_redox_2
FAD_oxidored
HI0933_like
Trp_halogenase
3HCDH_N
Pyr_redox
ApbA
TrkA_N
NAD_Gly3P_dh_N
NAD_binding_8
DAO
Trp_halogenase
GIDA
FAD_binding_2
SE

References:

TrkA_N
9478130 A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease. Trends Biochem Sci 1998;23:17-19.
8412700 NAD+ binding to the Escherichia coli K(+)-uptake protein TrkA and sequence similarity between TrkA and domains of a family of dehydrogenases suggest a role for NAD+ in bacterial transport. Mol Microbiol 1993;9:533-543.
11292341 Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. J Mol Biol 2001;307:1271-1292.

Shikimate_DH
7556173 The molecular biology of multidomain proteins. Selected examples. Eur J Biochem 1995;232:7-18.

FAD_binding_2
8061609 Structure of glutathione reductase from Escherichia coli at 1.86 A resolution: comparison with the enzyme from human erythrocytes. Protein Sci 1994;3:799-809.

3HCDH_N
3479790 Structure of L-3-hydroxyacyl-coenzyme A dehydrogenase: preliminary chain tracing at 2.8-A resolution. Proc Natl Acad Sci U S A 1987;84:8262-8266.

Lycopene_cycl
8837512 Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation. Plant Cell 1996;8:1613-1626.
11226339 One ring or two? Determination of ring number in carotenoids by lycopene epsilon-cyclases. Proc Natl Acad Sci U S A 2001;98:2905-2910.

ApbA
9488683 ApbA, the ketopantoate reductase enzyme of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway. J Biol Chem 1998;273:5572-5576.
9721324 The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium. J Bacteriol 1998;180:4757-4759.

Thi4
7961415 Cloning, nucleotide sequence, and regulation of Schizosaccharomyces pombe thi4, a thiamine biosynthetic gene. J Bacteriol 1994;176:6631-6635.

FAD_binding_3
1409567 Crystal structure of the reduced form of p-hydroxybenzoate hydroxylase refined at 2.3A resolution. Proteins 1992;14:178-190.

Pyr_redox_2
8805537 Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. Structure 1996;4:277-286.

DAO
9153426 Active site plasticity in D-amino acid oxidase: a crystallographic analysis. Biochemistry 1997;36:5853-5860.

HI0933_like

SE
9161422 Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans. Gene 1997;189:119-126.

DUF1188

GIDA

Pyr_redox
8805537 Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. Structure 1996;4:277-286.

FAD_oxidored

Trp_halogenase
10547442 Conservation of the pyrrolnitrin biosynthetic gene cluster among six pyrrolnitrin-producing strains. FEMS Microbiol Lett 1999;180:39-44.

NAD_binding_8

NAD_Gly3P_dh_N
12032156 Kinetic regulation of the mitochondrial glycerol-3-phosphate dehydrogenase by the external NADH dehydrogenase in Saccharomyces cerevisiae. J Biol Chem 2002;277:27991-27995.
10801498 A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana. Structure Fold Des 2000;8:541-552.

Domain	Description	Evalue	Bits	GA	Start	End
DUF1188	Protein of unknown function (DUF1188)	0.0002	11	26.50	28	75
Thi4	Thi4 family	7.2E-07	19	20.00	45	78
FAD_binding_3	FAD binding domain	2.3E-19	60	20.10	46	362
Shikimate_DH	Shikimate / quinate 5-dehydrogenase	0.00027	11	24.30	46	89
Lycopene_cycl	Lycopene cyclase protein	0.00028	10	23.40	47	75
DAO	FAD dependent oxidoreductase	1.9E-09	28	24.70	47	77
FAD_binding_2	FAD binding domain	1.5E-07	21	20.40	47	76
GIDA	Glucose inhibited division protein A	1.8E-05	14	20.00	47	76
Pyr_redox_2	Pyridine nucleotide-disulphide oxidoreductase	4.8E-07	20	22.80	47	81
FAD_oxidored	FAD dependent oxidoreductase	3.8E-06	17	27.00	47	77
HI0933_like	HI0933-like protein	6.3E-05	12	20.30	47	77
Trp_halogenase	Tryptophan halogenase	0.0052	6	19.60	47	77
3HCDH_N	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	7.4E-05	13	20.90	48	84
Pyr_redox	Pyridine nucleotide-disulphide oxidoreductase	1.2E-05	16	22.00	48	77
ApbA	Ketopantoate reductase PanE/ApbA	6.1E-05	13	21.70	48	77
TrkA_N	TrkA-N domain	0.00021	12	21.70	48	85
NAD_Gly3P_dh_N	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus	0.00031	11	23.10	48	82
NAD_binding_8	NAD(P)-binding Rossmann-like domain	5.2E-09	27	21.90	50	76
DAO	FAD dependent oxidoreductase	2E-06	18	24.70	139	213
Trp_halogenase	Tryptophan halogenase	0.019	4	19.60	144	212
GIDA	Glucose inhibited division protein A	0.00034	10	20.00	149	211
FAD_binding_2	FAD binding domain	0.016	5	20.40	151	213
SE	Squalene epoxidase	0	374	20.10	199	472