c2pfam

AT5G46450.1 :

Domain Description Evalue Bits GA Start End
TIR TIR domain 0 182 21.20 13 188
TIR_2 TIR domain 4.8E-14 44 28.00 15 107
AAA_16 AAA ATPase domain 1.4E-06 19 32.60 186 242
NB-ARC NB-ARC domain 1.6E-20 64 23.50 191 428
Rad17 Rad17 cell cycle checkpoint protein 4.7E-05 14 19.70 194 305
ATPase_2 ATPase domain predominantly from Archaea 1.5E-05 15 33.20 199 303
Pox_A32 Poxvirus A32 protein 2.9E-08 24 20.50 202 310
ABC_tran ABC transporter 4.1E-05 15 23.10 206 242
AAA_24 AAA domain 0.0002 12 27.00 209 235
NACHT NACHT domain 6E-06 17 20.40 209 304
AAA_18 AAA domain 8.7E-06 17 29.40 210 310
AAA_22 AAA domain 2.7E-06 18 27.00 210 303
PRK Phosphoribulokinase / Uridine kinase family 0.00019 12 20.60 210 291
AAA ATPase family associated with various cellular activities (AAA) 2.4E-07 22 20.80 212 303
RNA_helicase RNA helicase 8E-05 14 21.50 212 254
LRR_8 Leucine rich repeat 0.071 4 27.00 546 562
LRR_8 Leucine rich repeat 0.041 4 27.00 604 637
LRR_3 Leucine Rich Repeat 2.2E-09 27 20.20 606 624
LRR_8 Leucine rich repeat 0.00043 11 27.00 629 685
Sec3_C Exocyst complex component Sec3 0.00048 9 24.10 649 691
LRR_4 Leucine Rich repeats (2 copies) 0.28 2 27.00 651 691
LRR_1 Leucine Rich Repeat 0.0027 9 20.60 652 674
LRR_5 BspA type Leucine rich repeat region (6 copies) 0.00014 12 27.70 659 734
LRR_1 Leucine Rich Repeat 0.91 1 20.60 696 712
LRR_4 Leucine Rich repeats (2 copies) 0.2 3 27.00 723 750
LRR_3 Leucine Rich Repeat 0.013 6 20.20 751 761
Sec3_C Exocyst complex component Sec3 0.35 -1 24.10 766 821
LRR_8 Leucine rich repeat 1.2E-05 16 27.00 772 829
LRR_4 Leucine Rich repeats (2 copies) 5.6E-05 14 27.00 772 812
LRR_1 Leucine Rich Repeat 0.82 2 20.60 773 795
LRR_1 Leucine Rich Repeat 0.072 5 20.60 797 808
LRR_4 Leucine Rich repeats (2 copies) 1.6E-05 16 27.00 797 838
LRR_5 BspA type Leucine rich repeat region (6 copies) 0.03 5 27.70 805 835
LRR_1 Leucine Rich Repeat 0.73 2 20.60 821 835
LRR_4 Leucine Rich repeats (2 copies) 0.56 1 27.00 845 877
LRR_5 BspA type Leucine rich repeat region (6 copies) 0.078 4 27.70 872 905
LRR_8 Leucine rich repeat 0.12 3 27.00 872 901
LRR_4 Leucine Rich repeats (2 copies) 0.057 5 27.00 873 897
LRR_3 Leucine Rich Repeat 0.9 0 20.20 884 890

1123

TIR
TIR_2
AAA_16
NB-ARC
Rad17
ATPase_2
Pox_A32
ABC_tran
AAA_24
NACHT
AAA_18
AAA_22
PRK
AAA
RNA_helicase
LRR_8
LRR_8
LRR_3
LRR_8
Sec3_C
LRR_4
LRR_1
LRR_5
LRR_1
LRR_4
LRR_3
Sec3_C
LRR_8
LRR_4
LRR_1
LRR_1
LRR_4
LRR_5
LRR_1
LRR_4
LRR_5
LRR_8
LRR_4
LRR_3

References:

AAA_16

ABC_tran
1864505 Homology between proteins controlling Streptomyces fradiae tylosin resistance and ATP-binding transport. Gene 1991;102:27-32.
1977073 Structure and function of haemolysin B,P-glycoprotein and other members of a novel family of membrane translocators. Mol Microbiol 1990;4:873-880.
2229036 Binding protein-dependent transport systems. J Bioenerg Biomembr 1990;22:571-592.
9872322 Crystal structure of the ATP-binding subunit of an ABC transporter. Nature 1998;396:703-707.

AAA
7646486 A 200-amino acid ATPase module in search of a basic function. Bioessays 1995;17:639-650.
9927482 AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res 1999;9:27-43.

LRR_5

LRR_3
7817399 The leucine-rich repeat: a versatile binding motif. Trends Biochem Sci 1994;19:415-421.
8264799 Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature 1993;366:751-756.

LRR_1
7817399 The leucine-rich repeat: a versatile binding motif. Trends Biochem Sci 1994;19:415-421.
8264799 Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature 1993;366:751-756.

NB-ARC
9545207 The NB-ARC domain: a novel signalling motif shared by plant resistance gene products and regulators of cell death in animals. Curr Biol 1998;8:226-227.

LRR_8

PRK
9548738 The crystal structure of phosphoribulokinase from Rhodobacter sphaeroides reveals a fold similar to that of adenylate kinase. Biochemistry 1998;37:5074-5085.
17143579 Functional characterization of a gene encoding a dual domain for uridine kinase and uracil phosphoribosyltransferase in Arabidopsis thaliana. Plant Mol Biol. 2007;63:465-477.

LRR_4

ATPase_2

NACHT
10782090 The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation. Trends Biochem Sci 2000;25:223-224.

Rad17
10208430 hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation. Oncogene 1999;18:1689-1699.

TIR_2

RNA_helicase
2546125 Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res 1989;17:4713-4730.

AAA_24

TIR
9013863 The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. FEBS Lett 1997;402:81-84.
9237759 A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [see comments] Nature 1997;388:394-397.
12186654 Toll-like receptors: a family of pattern-recognition receptors in mammals. Genome Biol 2002;3:REVIEWS3011.

AAA_22

Pox_A32
9621036 DNA packaging mutant: repression of the vaccinia virus A32 gene results in noninfectious, DNA-deficient, spherical, enveloped particles. J Virol 1998;72:5769-5780.

Sec3_C

AAA_18

Domain	Description	Evalue	Bits	GA	Start	End
TIR	TIR domain	0	182	21.20	13	188
TIR_2	TIR domain	4.8E-14	44	28.00	15	107
AAA_16	AAA ATPase domain	1.4E-06	19	32.60	186	242
NB-ARC	NB-ARC domain	1.6E-20	64	23.50	191	428
Rad17	Rad17 cell cycle checkpoint protein	4.7E-05	14	19.70	194	305
ATPase_2	ATPase domain predominantly from Archaea	1.5E-05	15	33.20	199	303
Pox_A32	Poxvirus A32 protein	2.9E-08	24	20.50	202	310
ABC_tran	ABC transporter	4.1E-05	15	23.10	206	242
AAA_24	AAA domain	0.0002	12	27.00	209	235
NACHT	NACHT domain	6E-06	17	20.40	209	304
AAA_18	AAA domain	8.7E-06	17	29.40	210	310
AAA_22	AAA domain	2.7E-06	18	27.00	210	303
PRK	Phosphoribulokinase / Uridine kinase family	0.00019	12	20.60	210	291
AAA	ATPase family associated with various cellular activities (AAA)	2.4E-07	22	20.80	212	303
RNA_helicase	RNA helicase	8E-05	14	21.50	212	254
LRR_8	Leucine rich repeat	0.071	4	27.00	546	562
LRR_8	Leucine rich repeat	0.041	4	27.00	604	637
LRR_3	Leucine Rich Repeat	2.2E-09	27	20.20	606	624
LRR_8	Leucine rich repeat	0.00043	11	27.00	629	685
Sec3_C	Exocyst complex component Sec3	0.00048	9	24.10	649	691
LRR_4	Leucine Rich repeats (2 copies)	0.28	2	27.00	651	691
LRR_1	Leucine Rich Repeat	0.0027	9	20.60	652	674
LRR_5	BspA type Leucine rich repeat region (6 copies)	0.00014	12	27.70	659	734
LRR_1	Leucine Rich Repeat	0.91	1	20.60	696	712
LRR_4	Leucine Rich repeats (2 copies)	0.2	3	27.00	723	750
LRR_3	Leucine Rich Repeat	0.013	6	20.20	751	761
Sec3_C	Exocyst complex component Sec3	0.35	-1	24.10	766	821
LRR_8	Leucine rich repeat	1.2E-05	16	27.00	772	829
LRR_4	Leucine Rich repeats (2 copies)	5.6E-05	14	27.00	772	812
LRR_1	Leucine Rich Repeat	0.82	2	20.60	773	795
LRR_1	Leucine Rich Repeat	0.072	5	20.60	797	808
LRR_4	Leucine Rich repeats (2 copies)	1.6E-05	16	27.00	797	838
LRR_5	BspA type Leucine rich repeat region (6 copies)	0.03	5	27.70	805	835
LRR_1	Leucine Rich Repeat	0.73	2	20.60	821	835
LRR_4	Leucine Rich repeats (2 copies)	0.56	1	27.00	845	877
LRR_5	BspA type Leucine rich repeat region (6 copies)	0.078	4	27.70	872	905
LRR_8	Leucine rich repeat	0.12	3	27.00	872	901
LRR_4	Leucine Rich repeats (2 copies)	0.057	5	27.00	873	897
LRR_3	Leucine Rich Repeat	0.9	0	20.20	884	890