c2pfam

AT1G44120.1 :

Domain Description Evalue Bits GA Start End
UNC45-central Myosin-binding striated muscle assembly central 0.0094 6 24.50 21 58
Arm Armadillo/beta-catenin-like repeat 0.0071 7 20.60 52 86
Arm Armadillo/beta-catenin-like repeat 6.4E-05 13 20.60 99 123
HEAT_2 HEAT repeats 0.74 1 27.70 100 126
HEAT HEAT repeat 0.46 2 23.50 101 125
UNC45-central Myosin-binding striated muscle assembly central 0.00035 11 24.50 136 212
Arm Armadillo/beta-catenin-like repeat 0.34 1 20.60 145 176
Drf_GBD Diaphanous GTPase-binding Domain 0.046 3 21.30 155 218
Arm Armadillo/beta-catenin-like repeat 0.00015 12 20.60 187 217
E3_UbLigase_R4 E3 ubiquitin-protein ligase UBR4 0.058 2 23.00 188 252
HEAT_2 HEAT repeats 1.9E-05 15 27.70 190 257
DUF5578 Family of unknown function (DUF5578) 1 -1 25.70 191 218
HEAT HEAT repeat 0.04 5 23.50 193 219
UNC45-central Myosin-binding striated muscle assembly central 0.96 0 24.50 194 259
V-ATPase_H_C V-ATPase subunit H 0.16 2 20.80 194 256
RTP1_C1 Required for nuclear transport of RNA pol II C-terminus 1 0.0022 8 25.90 195 268
Cnd1 non-SMC mitotic condensation complex subunit 1 9.5E-05 13 26.40 195 295
HEAT_2 HEAT repeats 1.5E-05 16 27.70 195 268
Arm Armadillo/beta-catenin-like repeat 0.016 6 20.60 230 245
HEAT_EZ HEAT-like repeat 0.13 3 27.00 232 260
HEAT HEAT repeat 0.027 5 23.50 235 262
Atx10homo_assoc Spinocerebellar ataxia type 10 protein domain 0.53 1 22.40 249 289
RYDR_ITPR RIH domain 0.019 5 20.70 378 435
DUF5578 Family of unknown function (DUF5578) 0.28 1 25.70 452 520
Arm Armadillo/beta-catenin-like repeat 6.2E-05 13 20.60 481 518
E3_UbLigase_R4 E3 ubiquitin-protein ligase UBR4 0.00032 9 23.00 485 562
DUF5578 Family of unknown function (DUF5578) 0.056 3 25.70 488 640
HEAT_2 HEAT repeats 0.069 4 27.70 491 578
Atx10homo_assoc Spinocerebellar ataxia type 10 protein domain 0.08 3 22.40 507 538
Arm Armadillo/beta-catenin-like repeat 0.00034 11 20.60 524 556
Cnd1 non-SMC mitotic condensation complex subunit 1 0.27 1 26.40 540 634
Arm Armadillo/beta-catenin-like repeat 0.94 0 20.60 555 570
FAA_hydrolase_N Fumarylacetoacetase N-terminal 0.0004 11 25.00 586 635
PhageMin_Tail Phage-related minor tail protein 0.0047 7 30.00 604 693
Drf_GBD Diaphanous GTPase-binding Domain 0.54 0 21.30 611 636
Arm Armadillo/beta-catenin-like repeat 0.00074 10 20.60 611 636
HEAT_2 HEAT repeats 0.13 3 27.70 615 691
Cnd1 non-SMC mitotic condensation complex subunit 1 0.72 0 26.40 615 683
HEAT HEAT repeat 0.47 2 23.50 615 640
HEAT_2 HEAT repeats 0.82 0 27.70 666 708
TFCD_C Tubulin folding cofactor D C terminal 0.00014 12 21.40 741 827
HEAT_EZ HEAT-like repeat 0.48 1 27.00 833 862
Drf_GBD Diaphanous GTPase-binding Domain 0.1 2 21.30 834 864
HEAT_2 HEAT repeats 0.94 0 27.70 838 864
E3_UbLigase_R4 E3 ubiquitin-protein ligase UBR4 0.54 -2 23.00 999 1096
Drf_GBD Diaphanous GTPase-binding Domain 0.66 0 21.30 1004 1079
RYDR_ITPR RIH domain 0.52 0 20.70 1019 1118
Arm Armadillo/beta-catenin-like repeat 0.39 1 20.60 1152 1161
DUF5578 Family of unknown function (DUF5578) 3.9E-05 13 25.70 1173 1316
Arm Armadillo/beta-catenin-like repeat 0.077 4 20.60 1188 1210
HEAT_2 HEAT repeats 0.003 8 27.70 1242 1319
RTP1_C1 Required for nuclear transport of RNA pol II C-terminus 1 0.64 1 25.90 1384 1437
UNC45-central Myosin-binding striated muscle assembly central 0.2 2 24.50 1406 1480
HEAT HEAT repeat 0.45 2 23.50 1412 1435
Arm Armadillo/beta-catenin-like repeat 0.047 4 20.60 1439 1472
HEAT_EZ HEAT-like repeat 0.024 6 27.00 1513 1562
DUF5578 Family of unknown function (DUF5578) 0.47 0 25.70 1524 1572
HEAT_2 HEAT repeats 0.68 1 27.70 1527 1557
Cnd1 non-SMC mitotic condensation complex subunit 1 0.18 2 26.40 1611 1709
RTP1_C1 Required for nuclear transport of RNA pol II C-terminus 1 0.086 3 25.90 1615 1682
HEAT_2 HEAT repeats 0.3 2 27.70 1660 1713
Arm Armadillo/beta-catenin-like repeat 0.012 6 20.60 1693 1715
HEAT_2 HEAT repeats 0.003 8 27.70 1759 1812
HEAT_EZ HEAT-like repeat 0.1 4 27.00 1763 1810
Cnd1 non-SMC mitotic condensation complex subunit 1 0.55 0 26.40 1764 1822
V-ATPase_H_C V-ATPase subunit H 3.9E-05 14 20.80 1784 1855
Arm Armadillo/beta-catenin-like repeat 0.028 5 20.60 1785 1811
UNC45-central Myosin-binding striated muscle assembly central 0.19 2 24.50 1789 1849
E3_UbLigase_R4 E3 ubiquitin-protein ligase UBR4 0.096 1 23.00 1789 1933
RYDR_ITPR RIH domain 0.00039 10 20.70 1794 1877
DUF5578 Family of unknown function (DUF5578) 0.067 3 25.70 1798 1938
Atx10homo_assoc Spinocerebellar ataxia type 10 protein domain 0.55 1 22.40 1804 1863
Cnd1 non-SMC mitotic condensation complex subunit 1 0.026 5 26.40 1822 1877
HEAT_2 HEAT repeats 0.34 2 27.70 1830 1924
HEAT HEAT repeat 0.35 2 23.50 1831 1856
HEAT_EZ HEAT-like repeat 0.62 1 27.00 1908 1935
HEAT HEAT repeat 0.75 1 23.50 1913 1938
PhageMin_Tail Phage-related minor tail protein 0.22 2 30.00 1921 1956
C2 C2 domain 3.5E-16 50 20.90 1994 2089

2114

UNC45-central
Arm
Arm
HEAT_2
HEAT
UNC45-central
Arm
Drf_GBD
Arm
E3_UbLigase_R4
HEAT_2
DUF5578
HEAT
UNC45-central
V-ATPase_H_C
RTP1_C1
Cnd1
HEAT_2
Arm
HEAT_EZ
HEAT
Atx10homo_assoc
RYDR_ITPR
DUF5578
Arm
E3_UbLigase_R4
DUF5578
HEAT_2
Atx10homo_assoc
Arm
Cnd1
Arm
FAA_hydrolase_N
PhageMin_Tail
Drf_GBD
Arm
HEAT_2
Cnd1
HEAT
HEAT_2
TFCD_C
HEAT_EZ
Drf_GBD
HEAT_2
E3_UbLigase_R4
Drf_GBD
RYDR_ITPR
Arm
DUF5578
Arm
HEAT_2
RTP1_C1
UNC45-central
HEAT
Arm
HEAT_EZ
DUF5578
HEAT_2
Cnd1
RTP1_C1
HEAT_2
Arm
HEAT_2
HEAT_EZ
Cnd1
V-ATPase_H_C
Arm
UNC45-central
E3_UbLigase_R4
RYDR_ITPR
DUF5578
Atx10homo_assoc
Cnd1
HEAT_2
HEAT
HEAT_EZ
HEAT
PhageMin_Tail
C2

References:

RYDR_ITPR
10664581 Novel repeats in ryanodine and IP3 receptors and protein O-mannosyltransferases. Trends Biochem Sci 2000;25:48-50.

DUF5578

Atx10homo_assoc
15201271 Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons. J Biol Chem. 2004;279:35542-35550.

Arm
9298899 Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell 1997;90:871-882.
8573337 Signal transduction of beta-catenin. Curr Opin Cell Biol 1995;7:634-640.
9309175 Armadillo and dTCF: a marriage made in the nucleus. Curr Opin Genet Dev 1997;7:459-466.
8259519 Association of the APC tumor suppressor protein with catenins. Science 1993;262:1734-1737.
8259518 Association of the APC gene product with beta-catenin. Science 1993;262:1731-1734.
2261639 The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell 1990;63:1167-1176.

RTP1_C1

TFCD_C
10722852 Tubulin folding cofactor D is a microtubule destabilizing protein. FEBS Lett. 2000;470:93-95.

E3_UbLigase_R4

PhageMin_Tail

HEAT
7550332 HEAT repeats in the Huntington's disease protein. Nat Genet 1995;11:115-116.
9989501 The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell 1999;96:99-110.

V-ATPase_H_C
10954728 Regulation of yeast ectoapyrase ynd1p activity by activator subunit Vma13p of vacuolar H+-ATPase. J Biol Chem 2000;275:35592-35599.
18708638 Functional characterization of the N-terminal domain of subunit H (Vma13p) of the yeast vacuolar ATPase. J Biol Chem. 2008; [Epub ahead of print]
16141210 Structural and functional separation of the N- and C-terminal domains of the yeast V-ATPase subunit H. J Biol Chem. 2005;280:36978-36985.

HEAT_EZ

Cnd1

C2
8771209 Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin. Protein Sci 1996;5:162-166.

FAA_hydrolase_N

Drf_GBD
12676083 Disruption of the Diaphanous-Related Formin Drf1 Gene Encoding mDia1 Reveals a Role for Drf3 as an Effector for Cdc42. Curr Biol 2003;13:534-545.

UNC45-central
12356907 Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. J Cell Sci. 2002;115:4013-4023.
18523008 Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells. Proc Natl Acad Sci U S A. 2008;105:8014-8019.
18478096 Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain. PLoS ONE. 2008;3:e2137.

HEAT_2

Domain	Description	Evalue	Bits	GA	Start	End
UNC45-central	Myosin-binding striated muscle assembly central	0.0094	6	24.50	21	58
Arm	Armadillo/beta-catenin-like repeat	0.0071	7	20.60	52	86
Arm	Armadillo/beta-catenin-like repeat	6.4E-05	13	20.60	99	123
HEAT_2	HEAT repeats	0.74	1	27.70	100	126
HEAT	HEAT repeat	0.46	2	23.50	101	125
UNC45-central	Myosin-binding striated muscle assembly central	0.00035	11	24.50	136	212
Arm	Armadillo/beta-catenin-like repeat	0.34	1	20.60	145	176
Drf_GBD	Diaphanous GTPase-binding Domain	0.046	3	21.30	155	218
Arm	Armadillo/beta-catenin-like repeat	0.00015	12	20.60	187	217
E3_UbLigase_R4	E3 ubiquitin-protein ligase UBR4	0.058	2	23.00	188	252
HEAT_2	HEAT repeats	1.9E-05	15	27.70	190	257
DUF5578	Family of unknown function (DUF5578)	1	-1	25.70	191	218
HEAT	HEAT repeat	0.04	5	23.50	193	219
UNC45-central	Myosin-binding striated muscle assembly central	0.96	0	24.50	194	259
V-ATPase_H_C	V-ATPase subunit H	0.16	2	20.80	194	256
RTP1_C1	Required for nuclear transport of RNA pol II C-terminus 1	0.0022	8	25.90	195	268
Cnd1	non-SMC mitotic condensation complex subunit 1	9.5E-05	13	26.40	195	295
HEAT_2	HEAT repeats	1.5E-05	16	27.70	195	268
Arm	Armadillo/beta-catenin-like repeat	0.016	6	20.60	230	245
HEAT_EZ	HEAT-like repeat	0.13	3	27.00	232	260
HEAT	HEAT repeat	0.027	5	23.50	235	262
Atx10homo_assoc	Spinocerebellar ataxia type 10 protein domain	0.53	1	22.40	249	289
RYDR_ITPR	RIH domain	0.019	5	20.70	378	435
DUF5578	Family of unknown function (DUF5578)	0.28	1	25.70	452	520
Arm	Armadillo/beta-catenin-like repeat	6.2E-05	13	20.60	481	518
E3_UbLigase_R4	E3 ubiquitin-protein ligase UBR4	0.00032	9	23.00	485	562
DUF5578	Family of unknown function (DUF5578)	0.056	3	25.70	488	640
HEAT_2	HEAT repeats	0.069	4	27.70	491	578
Atx10homo_assoc	Spinocerebellar ataxia type 10 protein domain	0.08	3	22.40	507	538
Arm	Armadillo/beta-catenin-like repeat	0.00034	11	20.60	524	556
Cnd1	non-SMC mitotic condensation complex subunit 1	0.27	1	26.40	540	634
Arm	Armadillo/beta-catenin-like repeat	0.94	0	20.60	555	570
FAA_hydrolase_N	Fumarylacetoacetase N-terminal	0.0004	11	25.00	586	635
PhageMin_Tail	Phage-related minor tail protein	0.0047	7	30.00	604	693
Drf_GBD	Diaphanous GTPase-binding Domain	0.54	0	21.30	611	636
Arm	Armadillo/beta-catenin-like repeat	0.00074	10	20.60	611	636
HEAT_2	HEAT repeats	0.13	3	27.70	615	691
Cnd1	non-SMC mitotic condensation complex subunit 1	0.72	0	26.40	615	683
HEAT	HEAT repeat	0.47	2	23.50	615	640
HEAT_2	HEAT repeats	0.82	0	27.70	666	708
TFCD_C	Tubulin folding cofactor D C terminal	0.00014	12	21.40	741	827
HEAT_EZ	HEAT-like repeat	0.48	1	27.00	833	862
Drf_GBD	Diaphanous GTPase-binding Domain	0.1	2	21.30	834	864
HEAT_2	HEAT repeats	0.94	0	27.70	838	864
E3_UbLigase_R4	E3 ubiquitin-protein ligase UBR4	0.54	-2	23.00	999	1096
Drf_GBD	Diaphanous GTPase-binding Domain	0.66	0	21.30	1004	1079
RYDR_ITPR	RIH domain	0.52	0	20.70	1019	1118
Arm	Armadillo/beta-catenin-like repeat	0.39	1	20.60	1152	1161
DUF5578	Family of unknown function (DUF5578)	3.9E-05	13	25.70	1173	1316
Arm	Armadillo/beta-catenin-like repeat	0.077	4	20.60	1188	1210
HEAT_2	HEAT repeats	0.003	8	27.70	1242	1319
RTP1_C1	Required for nuclear transport of RNA pol II C-terminus 1	0.64	1	25.90	1384	1437
UNC45-central	Myosin-binding striated muscle assembly central	0.2	2	24.50	1406	1480
HEAT	HEAT repeat	0.45	2	23.50	1412	1435
Arm	Armadillo/beta-catenin-like repeat	0.047	4	20.60	1439	1472
HEAT_EZ	HEAT-like repeat	0.024	6	27.00	1513	1562
DUF5578	Family of unknown function (DUF5578)	0.47	0	25.70	1524	1572
HEAT_2	HEAT repeats	0.68	1	27.70	1527	1557
Cnd1	non-SMC mitotic condensation complex subunit 1	0.18	2	26.40	1611	1709
RTP1_C1	Required for nuclear transport of RNA pol II C-terminus 1	0.086	3	25.90	1615	1682
HEAT_2	HEAT repeats	0.3	2	27.70	1660	1713
Arm	Armadillo/beta-catenin-like repeat	0.012	6	20.60	1693	1715
HEAT_2	HEAT repeats	0.003	8	27.70	1759	1812
HEAT_EZ	HEAT-like repeat	0.1	4	27.00	1763	1810
Cnd1	non-SMC mitotic condensation complex subunit 1	0.55	0	26.40	1764	1822
V-ATPase_H_C	V-ATPase subunit H	3.9E-05	14	20.80	1784	1855
Arm	Armadillo/beta-catenin-like repeat	0.028	5	20.60	1785	1811
UNC45-central	Myosin-binding striated muscle assembly central	0.19	2	24.50	1789	1849
E3_UbLigase_R4	E3 ubiquitin-protein ligase UBR4	0.096	1	23.00	1789	1933
RYDR_ITPR	RIH domain	0.00039	10	20.70	1794	1877
DUF5578	Family of unknown function (DUF5578)	0.067	3	25.70	1798	1938
Atx10homo_assoc	Spinocerebellar ataxia type 10 protein domain	0.55	1	22.40	1804	1863
Cnd1	non-SMC mitotic condensation complex subunit 1	0.026	5	26.40	1822	1877
HEAT_2	HEAT repeats	0.34	2	27.70	1830	1924
HEAT	HEAT repeat	0.35	2	23.50	1831	1856
HEAT_EZ	HEAT-like repeat	0.62	1	27.00	1908	1935
HEAT	HEAT repeat	0.75	1	23.50	1913	1938
PhageMin_Tail	Phage-related minor tail protein	0.22	2	30.00	1921	1956
C2	C2 domain	3.5E-16	50	20.90	1994	2089