c2pfam

AT1G50450.1 :

Domain Description Evalue Bits GA Start End
Shikimate_DH Shikimate / quinate 5-dehydrogenase 1.8E-06 18 24.30 37 117
Semialdhyde_dh Semialdehyde dehydrogenase, NAD binding domain 1.4E-07 22 21.40 40 118
Ldh_1_N lactate/malate dehydrogenase, NAD binding domain 2.6E-07 21 20.40 40 120
DapB_N Dihydrodipicolinate reductase, N-terminus 4.2E-05 13 20.80 40 115
Sacchrp_dh_NADP Saccharopine dehydrogenase NADP binding domain 4.3E-22 69 25.10 41 160
Epimerase NAD dependent epimerase/dehydratase family 4.3E-07 19 20.60 41 118
KR KR domain 2.1E-06 17 22.60 41 121
NmrA NmrA-like family 9.5E-06 15 20.60 41 116
adh_short short chain dehydrogenase 1.1E-05 15 20.50 41 109
3Beta_HSD 3-beta hydroxysteroid dehydrogenase/isomerase family 2.7E-06 16 20.00 42 117
NAD_binding_10 NAD(P)H-binding 8.2E-07 19 27.20 45 130
Sacchrp_dh_C Saccharopine dehydrogenase C-terminal domain 3.8E-05 14 31.00 170 383

428

Shikimate_DH
Semialdhyde_dh
Ldh_1_N
DapB_N
Sacchrp_dh_NADP
Epimerase
KR
NmrA
adh_short
3Beta_HSD
NAD_binding_10
Sacchrp_dh_C

References:

NmrA
11726498 The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases. EMBO J 2001;20:6619-6626.

Semialdhyde_dh
10369777 Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis. J Mol Biol 1999;289:991-1002.

DapB_N
8873595 Interaction of pyridine nucleotide substrates with Escherichia coli dihydrodipicolinate reductase: thermodynamic and structural analysis of binary complexes. Biochemistry 1996;35:13294-13302.
9398235 Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate. Biochemistry 1997;36:15081-15088.
7893645 Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase. Biochemistry 1995;34:3502-3512.

Shikimate_DH
7556173 The molecular biology of multidomain proteins. Selected examples. Eur J Biochem 1995;232:7-18.

adh_short
9735295 The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 A resolution. J Mol Biol 1998;282:383-399.
10387002 Structure of tropinone reductase-II complexed with NADP+ and pseudotropine at 1.9 A resolution: implication for stereospecific substrate binding and catalysis. Biochemistry 1999;38:7630-7637.

3Beta_HSD
1562516 Structure and tissue-specific expression of 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues. J Steroid Biochem Mol Biol 1992;41:421-435.

KR

Epimerase
9174344 Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Biochemistry 1997;36:6294-6304.

Sacchrp_dh_NADP

Ldh_1_N
10075524 Structural basis of substrate specificity in malate dehydrogenases: crystal structure of a ternary complex of porcine cytoplasmic malate dehydrogenase, alpha-ketomalonate and tetrahydoNAD. J Mol Biol 1999;285:703-712.
12029364 Molecular evolution within the L-malate and L-lactate dehydrogenase super-family. J Mol Evol 2002;54:825-840.

NAD_binding_10

Sacchrp_dh_C

Domain	Description	Evalue	Bits	GA	Start	End
Shikimate_DH	Shikimate / quinate 5-dehydrogenase	1.8E-06	18	24.30	37	117
Semialdhyde_dh	Semialdehyde dehydrogenase, NAD binding domain	1.4E-07	22	21.40	40	118
Ldh_1_N	lactate/malate dehydrogenase, NAD binding domain	2.6E-07	21	20.40	40	120
DapB_N	Dihydrodipicolinate reductase, N-terminus	4.2E-05	13	20.80	40	115
Sacchrp_dh_NADP	Saccharopine dehydrogenase NADP binding domain	4.3E-22	69	25.10	41	160
Epimerase	NAD dependent epimerase/dehydratase family	4.3E-07	19	20.60	41	118
KR	KR domain	2.1E-06	17	22.60	41	121
NmrA	NmrA-like family	9.5E-06	15	20.60	41	116
adh_short	short chain dehydrogenase	1.1E-05	15	20.50	41	109
3Beta_HSD	3-beta hydroxysteroid dehydrogenase/isomerase family	2.7E-06	16	20.00	42	117
NAD_binding_10	NAD(P)H-binding	8.2E-07	19	27.20	45	130
Sacchrp_dh_C	Saccharopine dehydrogenase C-terminal domain	3.8E-05	14	31.00	170	383