c2pfam

AT1G67170.1 :

Domain Description Evalue Bits GA Start End
KxDL Uncharacterized conserved protein 0.0042 9 23.80 54 132
Tup_N Tup N-terminal 0.037 6 22.40 58 105
Filament Intermediate filament protein 0.0012 10 40.00 58 147
Yuri_gagarin Yuri gagarin 3.2E-05 15 28.00 59 195
ERM Ezrin/radixin/moesin family 0.002 9 30.00 59 234
Spc7 Spc7 kinetochore protein 0.016 5 34.00 63 142
ADIP Afadin- and alpha -actinin-Binding 0.0019 10 29.10 67 131
TMF_DNA_bd TATA element modulatory factor 1 DNA binding 0.046 5 35.00 68 110
TMF_TATA_bd TATA element modulatory factor 1 TATA binding 0.094 4 28.70 70 130
CENP-H Centromere protein H (CENP-H) 0.047 6 23.00 70 134
Crescentin Crescentin protein 0.00052 11 100.00 72 146
CENP-F_leu_zip Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 0.067 5 30.00 72 112
DUF2353 Uncharacterized coiled-coil protein (DUF2353) 3.6E-05 15 30.00 75 169
Golgin_A5 Golgin subfamily A member 5 0.0082 7 30.00 76 169
Baculo_PEP_C Baculovirus polyhedron envelope protein, PEP, C terminus 0.04 5 38.00 79 186
EzrA Septation ring formation regulator, EzrA 0.0015 8 30.00 83 243
OmpH Outer membrane protein (OmpH-like) 0.015 7 28.70 83 169
Fib_alpha Fibrinogen alpha/beta chain family 0.39 2 26.20 84 130
FlaC_arch Flagella accessory protein C (FlaC) 0.047 6 22.00 85 124
GAS Growth-arrest specific micro-tubule binding 0.022 5 32.30 85 169
Rootletin Ciliary rootlet component, centrosome cohesion 0.0041 9 31.60 85 176
FapA Flagellar Assembly Protein A 0.3 1 36.70 85 139
TPR_MLP1_2 TPR/MLP1/MLP2-like protein 0.00053 11 30.00 85 174
Seryl_tRNA_N Seryl-tRNA synthetase N-terminal domain 0.033 6 27.90 85 136
Tropomyosin_1 Tropomyosin like 0.008 8 34.20 86 213
FUSC Fusaric acid resistance protein family 0.0092 6 30.90 86 200
DUF4200 Domain of unknown function (DUF4200) 0.014 7 29.70 87 176
DUF4407 Domain of unknown function (DUF4407) 0.0017 9 31.30 87 217
CENP-F_leu_zip Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 0.00011 14 30.00 89 200
Fez1 Fez1 0.0045 9 25.00 90 238
Sec20 Sec20 0.61 2 27.00 92 150
CENP-F_N Cenp-F N-terminal domain 0.0004 11 20.20 94 227
Syntaxin_2 Syntaxin-like protein 0.0015 10 30.50 96 203
DUF1664 Protein of unknown function (DUF1664) 0.046 5 30.00 98 170
RPW8 Arabidopsis broad-spectrum mildew resistance protein RPW8 0.17 3 23.90 113 149
V_ATPase_I V-type ATPase 116kDa subunit family 0.00035 10 26.50 113 232
CENP-H Centromere protein H (CENP-H) 0.0027 10 23.00 119 198
FlaC_arch Flagella accessory protein C (FlaC) 0.19 4 22.00 121 162
TPR_MLP1_2 TPR/MLP1/MLP2-like protein 0.0031 9 30.00 121 228
TMF_TATA_bd TATA element modulatory factor 1 TATA binding 0.00014 13 28.70 122 198
ADIP Afadin- and alpha -actinin-Binding 0.012 7 29.10 125 177
GAS Growth-arrest specific micro-tubule binding 0.03 5 32.30 128 231
TRSP TRSP domain C terminus to PRTase_2 0.0011 10 25.00 132 175
Tup_N Tup N-terminal 6.4E-05 15 22.40 133 176
Seryl_tRNA_N Seryl-tRNA synthetase N-terminal domain 0.002 10 27.90 141 200
Golgin_A5 Golgin subfamily A member 5 0.012 6 30.00 144 237
DUF1664 Protein of unknown function (DUF1664) 0.0013 10 30.00 149 233
CDO_I Cysteine dioxygenase type I 0.00086 10 21.40 150 202
Crescentin Crescentin protein 0.099 3 100.00 151 173
Spc7 Spc7 kinetochore protein 0.00068 10 34.00 151 235
FapA Flagellar Assembly Protein A 0.00011 12 36.70 152 232
Fib_alpha Fibrinogen alpha/beta chain family 0.0025 9 26.20 152 237
ACR_tran AcrB/AcrD/AcrF family 0.0038 6 28.00 154 234
Sec20 Sec20 0.00097 10 27.00 154 203
KxDL Uncharacterized conserved protein 0.97 1 23.80 154 177
RPW8 Arabidopsis broad-spectrum mildew resistance protein RPW8 0.0013 10 23.90 157 228
Filament Intermediate filament protein 0.2 2 40.00 160 221
OmpH Outer membrane protein (OmpH-like) 0.0085 8 28.70 160 234
ADIP Afadin- and alpha -actinin-Binding 0.71 1 29.10 167 237
DUF2353 Uncharacterized coiled-coil protein (DUF2353) 0.36 1 30.00 169 225
Syntaxin_2 Syntaxin-like protein 0.021 7 30.50 172 232
Crescentin Crescentin protein 0.0066 7 100.00 174 237
TMF_DNA_bd TATA element modulatory factor 1 DNA binding 0.0028 9 35.00 175 233
FlaC_arch Flagella accessory protein C (FlaC) 0.39 3 22.00 175 192
KxDL Uncharacterized conserved protein 0.017 7 23.80 176 235
Tup_N Tup N-terminal 0.0024 10 22.40 179 232
Tropomyosin_1 Tropomyosin like 0.12 4 34.20 180 238
Rootletin Ciliary rootlet component, centrosome cohesion 0.019 6 31.60 180 232
DUF4200 Domain of unknown function (DUF4200) 0.78 2 29.70 182 242
Seryl_tRNA_N Seryl-tRNA synthetase N-terminal domain 0.082 5 27.90 183 232
CENP-H Centromere protein H (CENP-H) 0.44 2 23.00 210 236

359

KxDL
Tup_N
Filament
Yuri_gagarin
ERM
Spc7
ADIP
TMF_DNA_bd
TMF_TATA_bd
CENP-H
Crescentin
CENP-F_leu_zip
DUF2353
Golgin_A5
Baculo_PEP_C
EzrA
OmpH
Fib_alpha
FlaC_arch
GAS
Rootletin
FapA
TPR_MLP1_2
Seryl_tRNA_N
Tropomyosin_1
FUSC
DUF4200
DUF4407
CENP-F_leu_zip
Fez1
Sec20
CENP-F_N
Syntaxin_2
DUF1664
RPW8
V_ATPase_I
CENP-H
FlaC_arch
TPR_MLP1_2
TMF_TATA_bd
ADIP
GAS
TRSP
Tup_N
Seryl_tRNA_N
Golgin_A5
DUF1664
CDO_I
Crescentin
Spc7
FapA
Fib_alpha
ACR_tran
Sec20
KxDL
RPW8
Filament
OmpH
ADIP
DUF2353
Syntaxin_2
Crescentin
TMF_DNA_bd
FlaC_arch
KxDL
Tup_N
Tropomyosin_1
Rootletin
DUF4200
Seryl_tRNA_N
CENP-H

References:

OmpH
2318304 Bacterial 'histone-like protein I' (HLP-I) is an outer membrane constituent? FEBS Lett 1990;262:123-126.
15304217 Crystal structure of Skp, a prefoldin-like chaperone that protects soluble and membrane proteins from aggregation. Mol Cell 2004;15:367-374.

Fez1
10097140 The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. Proc Natl Acad Sci U S A 1999;96:3928-3933.
11504921 FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis. Proc Natl Acad Sci U S A 2001;98:10374-10379.

Syntaxin_2

TPR_MLP1_2
9024684 Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments. J Cell Biol 1997;136:515-529.
7798308 Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. J Cell Biol 1994;127:1515-1526.
10617624 Mlp2p, a component of nuclear pore attached intranuclear filaments, associates with nic96p. J Biol Chem 2000;275:343-350.
12490156 Myosin-like proteins 1 and 2 are not required for silencing or telomere anchoring, but act in the Tel1 pathway of telomere length control. J Struct Biol 2002;140:79-91.

Spc7
15371542 The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association. Mol Biol Cell 2004;15:5255-5267.

FapA

Seryl_tRNA_N
8654381 The crystal structure of the ternary complex of T.thermophilus seryl-tRNA synthetase with tRNA(Ser) and a seryl-adenylate analogue reveals a conformational switch in the active site. EMBO J 1996;15:2834-2842.

CENP-H
10488063 Characterization of a novel kinetochore protein, CENP-H. J Biol Chem 1999;274:27343-27346.
11500386 CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells. EMBO J 2001;20:4603-4617.

CENP-F_N
9704407 The vertebrate cell kinetochore and its roles during mitosis. Trends Cell Biol. 1998;8:310-318.
15939891 Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway. Proc Natl Acad Sci U S A. 2005;102:8549-8554.

CENP-F_leu_zip
7542657 CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. J Cell Biol. 1995;130:507-518.
14555653 LEK1 is a potential inhibitor of pocket protein-mediated cellular processes. J Biol Chem. 2004;279:664-676.

RPW8
11141561 Broad-spectrum mildew resistance in Arabidopsis thaliana mediated by RPW8. Science 2001;291:118-120.
12509520 Enhanced Transcription of the Arabidopsis Disease Resistance Genes RPW8.1 and RPW8.2 via a Salicylic Acid-Dependent Amplification Circuit Is Required for Hypersensitive Cell Death. Plant Cell 2003;15:33-45.

TRSP

Crescentin

Tropomyosin_1

TMF_TATA_bd
1409643 Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor. Proc Natl Acad Sci U S A. 1992;89:9372-9376.
15128430 TMF is a golgin that binds Rab6 and influences Golgi morphology. BMC Cell Biol. 2004;5:18.
18182439 Localization and domain characterization of Arabidopsis golgin candidates. J Exp Bot. 2007;58:4373-4386.

TMF_DNA_bd
9742951 Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases. FEBS Lett. 1998;434:339-345.
1409643 Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor. Proc Natl Acad Sci U S A. 1992;89:9372-9376.
15128430 TMF is a golgin that binds Rab6 and influences Golgi morphology. BMC Cell Biol. 2004;5:18.
18182439 Localization and domain characterization of Arabidopsis golgin candidates. J Exp Bot. 2007;58:4373-4386.

CDO_I

EzrA
10449747 Identification and characterization of a negative regulator of FtsZ ring formation in Bacillus subtilis. Proc Natl Acad Sci U S A 1999;96:9642-9647.

ADIP
12446711 ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions. J Biol Chem. 2003;278:4103-4111.
17486116 Gamma-tubulin complex-mediated anchoring of spindle microtubules to spindle-pole bodies requires Msd1 in fission yeast. Nat Cell Biol. 2007;9:646-653.

FUSC
1370369 Molecular cloning and characterization of the fusaric acid-resistance gene from Pseudomonas cepacia. Agric Biol Chem 1991;55:1913-1918.

FlaC_arch
11250034 The archaeal flagellum: a different kind of prokaryotic motility structure. FEMS Microbiol Rev 2001;25:147-174.
11717274 Characterization of flagellum gene families of methanogenic archaea and localization of novel flagellum accessory proteins. J Bacteriol 2001;183:7154-7164.

DUF2353

Yuri_gagarin

Rootletin

Tup_N
12234489 Mutations of the WD repeats that compromise Tup1 repression function maintain structural integrity of the WD domain trypsin-resistant core. Arch Biochem Biophys. 2002;406:47-54.

V_ATPase_I
10224039 Structure and properties of the vacuolar (H+)-ATPases. J Biol Chem 1999;274:12951-12954.
10340849 Structure and properties of the clathrin-coated vesicle and yeast vacuolar V-ATPases. J Bioenerg Biomembr 1999;31:57-65.

DUF1664

KxDL

DUF4200

ACR_tran
12374972 Crystal structure of bacterial multidrug efflux transporter AcrB. Nature 2002;419:587-593.

Golgin_A5
12656988 Golgin-84 is a rab1 binding partner involved in Golgi structure. Traffic. 2003;4:153-161.

Filament
8771189 Intermediate filament proteins. Protein Profile 1995;2:801-951.

DUF4407

ERM
9472040 Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol 1998;140:885-895.

Baculo_PEP_C
8176372 Orgyia pseudotsugata baculovirus p10 and polyhedron envelope protein genes: analysis of their relative expression levels and role in polyhedron structure. J Gen Virol 1994;75:1115-1123.

Fib_alpha
11601975 Crystal structure of native chicken fibrinogen at 2.7 A resolution. Biochemistry. 2001;40:12515-12523.

Sec20
8334998 The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p. EMBO J 1993;12:2831-2840.

GAS

Domain	Description	Evalue	Bits	GA	Start	End
KxDL	Uncharacterized conserved protein	0.0042	9	23.80	54	132
Tup_N	Tup N-terminal	0.037	6	22.40	58	105
Filament	Intermediate filament protein	0.0012	10	40.00	58	147
Yuri_gagarin	Yuri gagarin	3.2E-05	15	28.00	59	195
ERM	Ezrin/radixin/moesin family	0.002	9	30.00	59	234
Spc7	Spc7 kinetochore protein	0.016	5	34.00	63	142
ADIP	Afadin- and alpha -actinin-Binding	0.0019	10	29.10	67	131
TMF_DNA_bd	TATA element modulatory factor 1 DNA binding	0.046	5	35.00	68	110
TMF_TATA_bd	TATA element modulatory factor 1 TATA binding	0.094	4	28.70	70	130
CENP-H	Centromere protein H (CENP-H)	0.047	6	23.00	70	134
Crescentin	Crescentin protein	0.00052	11	100.00	72	146
CENP-F_leu_zip	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1	0.067	5	30.00	72	112
DUF2353	Uncharacterized coiled-coil protein (DUF2353)	3.6E-05	15	30.00	75	169
Golgin_A5	Golgin subfamily A member 5	0.0082	7	30.00	76	169
Baculo_PEP_C	Baculovirus polyhedron envelope protein, PEP, C terminus	0.04	5	38.00	79	186
EzrA	Septation ring formation regulator, EzrA	0.0015	8	30.00	83	243
OmpH	Outer membrane protein (OmpH-like)	0.015	7	28.70	83	169
Fib_alpha	Fibrinogen alpha/beta chain family	0.39	2	26.20	84	130
FlaC_arch	Flagella accessory protein C (FlaC)	0.047	6	22.00	85	124
GAS	Growth-arrest specific micro-tubule binding	0.022	5	32.30	85	169
Rootletin	Ciliary rootlet component, centrosome cohesion	0.0041	9	31.60	85	176
FapA	Flagellar Assembly Protein A	0.3	1	36.70	85	139
TPR_MLP1_2	TPR/MLP1/MLP2-like protein	0.00053	11	30.00	85	174
Seryl_tRNA_N	Seryl-tRNA synthetase N-terminal domain	0.033	6	27.90	85	136
Tropomyosin_1	Tropomyosin like	0.008	8	34.20	86	213
FUSC	Fusaric acid resistance protein family	0.0092	6	30.90	86	200
DUF4200	Domain of unknown function (DUF4200)	0.014	7	29.70	87	176
DUF4407	Domain of unknown function (DUF4407)	0.0017	9	31.30	87	217
CENP-F_leu_zip	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1	0.00011	14	30.00	89	200
Fez1	Fez1	0.0045	9	25.00	90	238
Sec20	Sec20	0.61	2	27.00	92	150
CENP-F_N	Cenp-F N-terminal domain	0.0004	11	20.20	94	227
Syntaxin_2	Syntaxin-like protein	0.0015	10	30.50	96	203
DUF1664	Protein of unknown function (DUF1664)	0.046	5	30.00	98	170
RPW8	Arabidopsis broad-spectrum mildew resistance protein RPW8	0.17	3	23.90	113	149
V_ATPase_I	V-type ATPase 116kDa subunit family	0.00035	10	26.50	113	232
CENP-H	Centromere protein H (CENP-H)	0.0027	10	23.00	119	198
FlaC_arch	Flagella accessory protein C (FlaC)	0.19	4	22.00	121	162
TPR_MLP1_2	TPR/MLP1/MLP2-like protein	0.0031	9	30.00	121	228
TMF_TATA_bd	TATA element modulatory factor 1 TATA binding	0.00014	13	28.70	122	198
ADIP	Afadin- and alpha -actinin-Binding	0.012	7	29.10	125	177
GAS	Growth-arrest specific micro-tubule binding	0.03	5	32.30	128	231
TRSP	TRSP domain C terminus to PRTase_2	0.0011	10	25.00	132	175
Tup_N	Tup N-terminal	6.4E-05	15	22.40	133	176
Seryl_tRNA_N	Seryl-tRNA synthetase N-terminal domain	0.002	10	27.90	141	200
Golgin_A5	Golgin subfamily A member 5	0.012	6	30.00	144	237
DUF1664	Protein of unknown function (DUF1664)	0.0013	10	30.00	149	233
CDO_I	Cysteine dioxygenase type I	0.00086	10	21.40	150	202
Crescentin	Crescentin protein	0.099	3	100.00	151	173
Spc7	Spc7 kinetochore protein	0.00068	10	34.00	151	235
FapA	Flagellar Assembly Protein A	0.00011	12	36.70	152	232
Fib_alpha	Fibrinogen alpha/beta chain family	0.0025	9	26.20	152	237
ACR_tran	AcrB/AcrD/AcrF family	0.0038	6	28.00	154	234
Sec20	Sec20	0.00097	10	27.00	154	203
KxDL	Uncharacterized conserved protein	0.97	1	23.80	154	177
RPW8	Arabidopsis broad-spectrum mildew resistance protein RPW8	0.0013	10	23.90	157	228
Filament	Intermediate filament protein	0.2	2	40.00	160	221
OmpH	Outer membrane protein (OmpH-like)	0.0085	8	28.70	160	234
ADIP	Afadin- and alpha -actinin-Binding	0.71	1	29.10	167	237
DUF2353	Uncharacterized coiled-coil protein (DUF2353)	0.36	1	30.00	169	225
Syntaxin_2	Syntaxin-like protein	0.021	7	30.50	172	232
Crescentin	Crescentin protein	0.0066	7	100.00	174	237
TMF_DNA_bd	TATA element modulatory factor 1 DNA binding	0.0028	9	35.00	175	233
FlaC_arch	Flagella accessory protein C (FlaC)	0.39	3	22.00	175	192
KxDL	Uncharacterized conserved protein	0.017	7	23.80	176	235
Tup_N	Tup N-terminal	0.0024	10	22.40	179	232
Tropomyosin_1	Tropomyosin like	0.12	4	34.20	180	238
Rootletin	Ciliary rootlet component, centrosome cohesion	0.019	6	31.60	180	232
DUF4200	Domain of unknown function (DUF4200)	0.78	2	29.70	182	242
Seryl_tRNA_N	Seryl-tRNA synthetase N-terminal domain	0.082	5	27.90	183	232
CENP-H	Centromere protein H (CENP-H)	0.44	2	23.00	210	236