c2pfam

AT2G17200.1 :

Domain Description Evalue Bits GA Start End
Ubiquitin_2 Ubiquitin-like domain 1.7E-05 16 23.10 18 87
Rad60-SLD_2 Ubiquitin-2 like Rad60 SUMO-like 3.1E-05 14 23.00 18 83
UN_NPL4 Nuclear pore localisation protein NPL4 5.6E-05 14 21.90 20 64
Rad60-SLD Ubiquitin-2 like Rad60 SUMO-like 6.7E-11 32 23.70 20 87
ubiquitin Ubiquitin family 5.5E-25 77 20.70 20 87
Ubiquitin_5 Ubiquitin-like domain 1.4E-05 16 23.20 28 81
DUF2407 Putative membrane protein (DUF2407) 3.1E-05 15 26.10 31 75
TBK1_ULD TANK binding kinase 1 ubiquitin-like domain 5.4E-06 17 31.00 35 72
NICE-1 Cysteine-rich C-terminal 1 family 7.6E-05 14 27.00 88 133
RPN13_C UCH-binding domain 0.0089 7 39.30 159 217
STI1 STI1 domain 0.0037 8 29.10 167 190
STI1 STI1 domain 0.0017 9 29.10 167 200
HECW1_helix Helical box domain of E3 ubiquitin-protein ligase HECW1 0.0027 8 25.00 173 215
Mod_r Modifier of rudimentary (Mod(r)) protein 0.11 3 27.00 179 209
GerD Spore germination GerD central core domain 0.092 3 29.50 179 202
STI1 STI1 domain 1.5E-05 15 29.10 198 240
GerD Spore germination GerD central core domain 0.55 1 29.50 213 239
Mod_r Modifier of rudimentary (Mod(r)) protein 0.9 0 27.00 383 424
RPN13_C UCH-binding domain 0.016 6 39.30 383 458
STI1 STI1 domain 1.4E-05 15 29.10 383 420
GerD Spore germination GerD central core domain 0.00056 10 29.50 384 440
HECW1_helix Helical box domain of E3 ubiquitin-protein ligase HECW1 0.062 4 25.00 387 431
STI1 STI1 domain 0.012 6 29.10 415 440
Mod_r Modifier of rudimentary (Mod(r)) protein 0.0011 9 27.00 423 466
GerD Spore germination GerD central core domain 0.11 3 29.50 427 456
HECW1_helix Helical box domain of E3 ubiquitin-protein ligase HECW1 0.17 3 25.00 430 458
UBA UBA/TS-N domain 1E-14 44 21.10 509 545
CUE CUE domain 0.63 0 20.40 512 519
HOIP-UBA HOIP UBA domain pair 0.00028 11 22.40 512 545
CUE CUE domain 1.1E-05 15 20.40 526 546

551

Ubiquitin_2
Rad60-SLD_2
UN_NPL4
Rad60-SLD
ubiquitin
Ubiquitin_5
DUF2407
TBK1_ULD
NICE-1
RPN13_C
STI1
STI1
HECW1_helix
Mod_r
GerD
STI1
GerD
Mod_r
RPN13_C
STI1
GerD
HECW1_helix
STI1
Mod_r
GerD
HECW1_helix
UBA
CUE
HOIP-UBA
CUE

References:

ubiquitin
3041007 Structure of ubiquitin refined at 1.8 A resolution. J Mol Biol 1987;194:531-544.
8107144 Structure of tetraubiquitin shows how multiubiquitin chains can be formed. J Mol Biol 1994;236:601-609.
9654451 Structure determination of the small ubiquitin-related modifier SUMO-1. J Mol Biol 1998;280:275-286.
9857030 Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. J Biol Chem 1998;273:34983-34991.
12826399 A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins. Trends Biochem Sci 2003;28:280-283.

STI1

CUE
9388185 Role of Cue1p in ubiquitination and degradation at the ER surface. Science 1997;278:1806-1809.
11023840 Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction. Biochem J 2000;351:527-535.
12573224 Ubiquitin Signals Protein Trafficking via Interaction with a Novel Ubiquitin Binding Domain in the Membrane Fusion Regulator, Vps9p. Curr Biol 2003;13:258-262.
12628920 A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J 2003;22:1273-1281.
12787503 Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding. Cell 2003;113:621-630.

RPN13_C

UBA
9846873 Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr. Nat Struct Biol 1998;5:1042-1047.
10413400 Comparative genomics of the Archaea (Euryarchaeota): evolution of conserved protein families, the stable core, and the variable shell. Genome Res 1999;9:608-628.
8596629 The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution. Nature 1996;379:511-518.

Ubiquitin_2

Ubiquitin_5

Rad60-SLD
15660128 Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. EMBO J. 2005;24:439-451.
19363481 Molecular mimicry of SUMO promotes DNA repair. Nat Struct Mol Biol. 2009;16:509-516.

HECW1_helix

NICE-1

DUF2407

GerD

Rad60-SLD_2

HOIP-UBA

TBK1_ULD

Mod_r
7651329 Modifier of rudimentary p1, mod(r)p1, a trans-acting regulatory mutation of rudimentary. Mol Gen Genet 1995;248:69-78.
15240819 The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell 2004;15:4337-4346.

UN_NPL4
17491009 Detailed structural insights into the p97-Npl4-Ufd1 interface. J Biol Chem. 2007;282:21361-21369.

Domain	Description	Evalue	Bits	GA	Start	End
Ubiquitin_2	Ubiquitin-like domain	1.7E-05	16	23.10	18	87
Rad60-SLD_2	Ubiquitin-2 like Rad60 SUMO-like	3.1E-05	14	23.00	18	83
UN_NPL4	Nuclear pore localisation protein NPL4	5.6E-05	14	21.90	20	64
Rad60-SLD	Ubiquitin-2 like Rad60 SUMO-like	6.7E-11	32	23.70	20	87
ubiquitin	Ubiquitin family	5.5E-25	77	20.70	20	87
Ubiquitin_5	Ubiquitin-like domain	1.4E-05	16	23.20	28	81
DUF2407	Putative membrane protein (DUF2407)	3.1E-05	15	26.10	31	75
TBK1_ULD	TANK binding kinase 1 ubiquitin-like domain	5.4E-06	17	31.00	35	72
NICE-1	Cysteine-rich C-terminal 1 family	7.6E-05	14	27.00	88	133
RPN13_C	UCH-binding domain	0.0089	7	39.30	159	217
STI1	STI1 domain	0.0037	8	29.10	167	190
STI1	STI1 domain	0.0017	9	29.10	167	200
HECW1_helix	Helical box domain of E3 ubiquitin-protein ligase HECW1	0.0027	8	25.00	173	215
Mod_r	Modifier of rudimentary (Mod(r)) protein	0.11	3	27.00	179	209
GerD	Spore germination GerD central core domain	0.092	3	29.50	179	202
STI1	STI1 domain	1.5E-05	15	29.10	198	240
GerD	Spore germination GerD central core domain	0.55	1	29.50	213	239
Mod_r	Modifier of rudimentary (Mod(r)) protein	0.9	0	27.00	383	424
RPN13_C	UCH-binding domain	0.016	6	39.30	383	458
STI1	STI1 domain	1.4E-05	15	29.10	383	420
GerD	Spore germination GerD central core domain	0.00056	10	29.50	384	440
HECW1_helix	Helical box domain of E3 ubiquitin-protein ligase HECW1	0.062	4	25.00	387	431
STI1	STI1 domain	0.012	6	29.10	415	440
Mod_r	Modifier of rudimentary (Mod(r)) protein	0.0011	9	27.00	423	466
GerD	Spore germination GerD central core domain	0.11	3	29.50	427	456
HECW1_helix	Helical box domain of E3 ubiquitin-protein ligase HECW1	0.17	3	25.00	430	458
UBA	UBA/TS-N domain	1E-14	44	21.10	509	545
CUE	CUE domain	0.63	0	20.40	512	519
HOIP-UBA	HOIP UBA domain pair	0.00028	11	22.40	512	545
CUE	CUE domain	1.1E-05	15	20.40	526	546