c2pfam

AT2G20190.1 :

Domain Description Evalue Bits GA Start End
RTP1_C1 Required for nuclear transport of RNA pol II C-terminus 1 0.018 6 25.90 2 67
HEAT_2 HEAT repeats 4.3E-05 15 27.70 6 105
MMS19_N NER and RNAPII transcription protein n terminal 3.8E-06 17 21.40 9 112
V-ATPase_H_C V-ATPase subunit H 0.48 1 20.80 20 67
Dopey_N Dopey, N-terminal 0.12 2 25.20 23 74
SEN1_N SEN1 N terminal 0.44 -1 24.60 24 122
Adaptin_N Adaptin N terminal region 0.18 1 20.30 37 71
Cnd1 non-SMC mitotic condensation complex subunit 1 0.022 5 26.40 38 111
HEAT HEAT repeat 0.26 3 23.50 42 66
ParcG Parkin co-regulated protein 0.2 2 20.60 45 88
Dopey_N Dopey, N-terminal 0.13 2 25.20 47 115
CLASP_N CLASP N terminal 3.2E-08 24 27.00 57 185
Vac14_Fab1_bd Vacuolar 14 Fab1-binding region 8.6E-05 14 22.10 59 112
HEAT_EZ HEAT-like repeat 8.1E-08 23 27.00 60 106
Tti2 Tti2 family 0.022 5 24.60 73 116
HEAT HEAT repeat 0.0014 10 23.50 83 112
RTP1_C1 Required for nuclear transport of RNA pol II C-terminus 1 0.12 3 25.90 88 198
HEAT_EZ HEAT-like repeat 2.4E-07 22 27.00 132 186
HEAT_2 HEAT repeats 0.00034 12 27.70 139 186
Vac14_Fab1_bd Vacuolar 14 Fab1-binding region 0.093 4 22.10 145 179
DUF1981 Domain of unknown function (DUF1981) 0.022 5 20.90 156 192
V-ATPase_H_N V-ATPase subunit H 0.36 1 20.10 157 201
Adaptin_N Adaptin N terminal region 0.00038 10 20.30 157 197
DUF3361 Domain of unknown function (DUF3361) 0.23 2 27.20 157 201
Tti2 Tti2 family 0.066 3 24.60 159 186
Ecm29 Proteasome stabiliser 0.56 -1 20.70 159 180
MMS19_C RNAPII transcription regulator C-terminal 0.47 0 32.90 160 193
HEAT HEAT repeat 2.6E-07 21 23.50 160 186
Cnd1 non-SMC mitotic condensation complex subunit 1 0.00051 11 26.40 161 189
RasGEF_N_2 Rapamycin-insensitive companion of mTOR RasGEF_N domain 0.035 5 27.00 162 189
V-ATPase_H_C V-ATPase subunit H 0.045 5 20.80 164 188
CLASP_N CLASP N terminal 0 156 27.00 284 500
Cnd1 non-SMC mitotic condensation complex subunit 1 0.038 5 26.40 322 383
Sec7_N Guanine nucleotide exchange factor in Golgi transport N-terminal 0.06 4 27.30 325 381
ParcG Parkin co-regulated protein 0.71 1 20.60 327 361
Adaptin_N Adaptin N terminal region 0.74 -1 20.30 346 405
Cnd1 non-SMC mitotic condensation complex subunit 1 0.24 2 26.40 445 473
Tti2 Tti2 family 0.077 3 24.60 748 870
V-ATPase_H_C V-ATPase subunit H 0.09 4 20.80 790 864
CLASP_N CLASP N terminal 3.4E-12 37 27.00 794 991
MMS19_N NER and RNAPII transcription protein n terminal 0.028 4 21.40 796 885
ParcG Parkin co-regulated protein 0.002 9 20.60 798 922
RTP1_C1 Required for nuclear transport of RNA pol II C-terminus 1 0.02 6 25.90 806 869
Ecm29 Proteasome stabiliser 0.39 0 20.70 809 939
Cnd1 non-SMC mitotic condensation complex subunit 1 0.0097 7 26.40 812 881
V-ATPase_H_N V-ATPase subunit H 0.0042 7 20.10 815 901
HEAT_EZ HEAT-like repeat 0.018 6 27.00 819 861
SEN1_N SEN1 N terminal 8.5E-05 11 24.60 822 972
Vac14_Fab1_bd Vacuolar 14 Fab1-binding region 0.028 6 22.10 830 896
Adaptin_N Adaptin N terminal region 3.3E-05 13 20.30 834 991
Sec7_N Guanine nucleotide exchange factor in Golgi transport N-terminal 0.01 6 27.30 835 915
DUF3361 Domain of unknown function (DUF3361) 0.98 0 27.20 836 873
RasGEF_N_2 Rapamycin-insensitive companion of mTOR RasGEF_N domain 0.012 7 27.00 837 866
HEAT HEAT repeat 0.00014 13 23.50 837 867
HEAT_2 HEAT repeats 4.6E-05 14 27.70 840 932
MMS19_C RNAPII transcription regulator C-terminal 0.14 2 32.90 841 891
HEAT HEAT repeat 0.22 3 23.50 878 901
MMS19_N NER and RNAPII transcription protein n terminal 0.37 1 21.40 904 946
MMS19_C RNAPII transcription regulator C-terminal 0.9 -1 32.90 911 935
Ecm29 Proteasome stabiliser 0.77 -1 20.70 939 1036
DUF3361 Domain of unknown function (DUF3361) 0.011 6 27.20 1213 1314
Vac14_Fab1_bd Vacuolar 14 Fab1-binding region 3.7E-06 18 22.10 1225 1313
Dopey_N Dopey, N-terminal 0.047 3 25.20 1232 1290
MMS19_C RNAPII transcription regulator C-terminal 0.0015 8 32.90 1242 1299
V-ATPase_H_C V-ATPase subunit H 0.46 1 20.80 1242 1280
Tti2 Tti2 family 2.3E-05 15 24.60 1244 1284
ParcG Parkin co-regulated protein 0.58 1 20.60 1248 1283
ParcG Parkin co-regulated protein 0.59 1 20.60 1249 1304
V-ATPase_H_N V-ATPase subunit H 0.00095 9 20.10 1249 1320
Sec7_N Guanine nucleotide exchange factor in Golgi transport N-terminal 0.00024 12 27.30 1251 1302
Cnd1 non-SMC mitotic condensation complex subunit 1 0.00047 11 26.40 1251 1369
HEAT HEAT repeat 0.13 4 23.50 1252 1280
RasGEF_N_2 Rapamycin-insensitive companion of mTOR RasGEF_N domain 0.64 1 27.00 1254 1300
Telomere_reg-2 Telomere length regulation protein 0.0025 9 20.90 1255 1336
RTP1_C1 Required for nuclear transport of RNA pol II C-terminus 1 0.039 5 25.90 1256 1305
Adaptin_N Adaptin N terminal region 0.00089 8 20.30 1256 1392
HEAT_2 HEAT repeats 0.85 1 27.70 1257 1312
DUF1981 Domain of unknown function (DUF1981) 0.0017 9 20.90 1262 1316
Ecm29 Proteasome stabiliser 0.026 4 20.70 1262 1324
MMS19_N NER and RNAPII transcription protein n terminal 0.22 2 21.40 1268 1330
CLASP_N CLASP N terminal 1.4E-05 15 27.00 1271 1331
SEN1_N SEN1 N terminal 0.5 -1 24.60 1282 1366
HEAT_2 HEAT repeats 0.25 2 27.70 1297 1354
MMS19_C RNAPII transcription regulator C-terminal 0.0011 9 32.90 1329 1395
MMS19_N NER and RNAPII transcription protein n terminal 0.23 2 21.40 1335 1375
ParcG Parkin co-regulated protein 0.11 3 20.60 1336 1411
Dopey_N Dopey, N-terminal 0.00035 10 25.20 1350 1411
HEAT_EZ HEAT-like repeat 0.047 5 27.00 1356 1393
Ecm29 Proteasome stabiliser 0.0015 8 20.70 1359 1397
CLASP_N CLASP N terminal 0.043 4 27.00 1360 1429
Vac14_Fab1_bd Vacuolar 14 Fab1-binding region 0.031 6 22.10 1361 1421
HEAT_2 HEAT repeats 0.021 6 27.70 1369 1417
HEAT HEAT repeat 0.00015 13 23.50 1370 1396

1439

RTP1_C1
HEAT_2
MMS19_N
V-ATPase_H_C
Dopey_N
SEN1_N
Adaptin_N
Cnd1
HEAT
ParcG
Dopey_N
CLASP_N
Vac14_Fab1_bd
HEAT_EZ
Tti2
HEAT
RTP1_C1
HEAT_EZ
HEAT_2
Vac14_Fab1_bd
DUF1981
V-ATPase_H_N
Adaptin_N
DUF3361
Tti2
Ecm29
MMS19_C
HEAT
Cnd1
RasGEF_N_2
V-ATPase_H_C
CLASP_N
Cnd1
Sec7_N
ParcG
Adaptin_N
Cnd1
Tti2
V-ATPase_H_C
CLASP_N
MMS19_N
ParcG
RTP1_C1
Ecm29
Cnd1
V-ATPase_H_N
HEAT_EZ
SEN1_N
Vac14_Fab1_bd
Adaptin_N
Sec7_N
DUF3361
RasGEF_N_2
HEAT
HEAT_2
MMS19_C
HEAT
MMS19_N
MMS19_C
Ecm29
DUF3361
Vac14_Fab1_bd
Dopey_N
MMS19_C
V-ATPase_H_C
Tti2
ParcG
ParcG
V-ATPase_H_N
Sec7_N
Cnd1
HEAT
RasGEF_N_2
Telomere_reg-2
RTP1_C1
Adaptin_N
HEAT_2
DUF1981
Ecm29
MMS19_N
CLASP_N
SEN1_N
HEAT_2
MMS19_C
MMS19_N
ParcG
Dopey_N
HEAT_EZ
Ecm29
CLASP_N
Vac14_Fab1_bd
HEAT_2
HEAT

References:

V-ATPase_H_N
10954728 Regulation of yeast ectoapyrase ynd1p activity by activator subunit Vma13p of vacuolar H+-ATPase. J Biol Chem 2000;275:35592-35599.
18708638 Functional characterization of the N-terminal domain of subunit H (Vma13p) of the yeast vacuolar ATPase. J Biol Chem. 2008; [Epub ahead of print]
16141210 Structural and functional separation of the N- and C-terminal domains of the yeast V-ATPase subunit H. J Biol Chem. 2005;280:36978-36985.

V-ATPase_H_C
10954728 Regulation of yeast ectoapyrase ynd1p activity by activator subunit Vma13p of vacuolar H+-ATPase. J Biol Chem 2000;275:35592-35599.
18708638 Functional characterization of the N-terminal domain of subunit H (Vma13p) of the yeast vacuolar ATPase. J Biol Chem. 2008; [Epub ahead of print]
16141210 Structural and functional separation of the N- and C-terminal domains of the yeast V-ATPase subunit H. J Biol Chem. 2005;280:36978-36985.

DUF3361

CLASP_N
16951255 S. pombe CLASP needs dynein, not EB1 or CLIP170, to induce microtubule instability and slows polymerization rates at cell tips in a dynein-dependent manner. Genes Dev. 2006;20:2421-2436.
16914514 Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. Mol Biol Cell. 2006;17:4526-4542.

RasGEF_N_2

Adaptin_N
9261055 Linking cargo to vesicle formation: receptor tail interactions with coat proteins. Curr Opin Cell Biol 1997;9:488-495.
2495531 Structural and functional division into two domains of the large (100- to 115-kDa)chains of the clathrin-associated protein complex AP-2. Proc Natl Acad Sci U S A 1989;86:2612-2616.

DUF1981

Vac14_Fab1_bd

Telomere_reg-2
11641227 The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Development. 2001;128:4045-4055.

MMS19_N
11328871 Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant. Nucleic Acids Res. 2001;29:1884-1891.

Tti2

HEAT
7550332 HEAT repeats in the Huntington's disease protein. Nat Genet 1995;11:115-116.
9989501 The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell 1999;96:99-110.

SEN1_N

Dopey_N
10931277 Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. Mol Microbiol 2000;36:1250-1264.

Cnd1

HEAT_EZ

Sec7_N

Ecm29

MMS19_C

ParcG
12547187 Identification of a novel gene linked to parkin via a bi-directional promoter. J Mol Biol. 2003;326:11-19.

RTP1_C1

HEAT_2

Domain	Description	Evalue	Bits	GA	Start	End
RTP1_C1	Required for nuclear transport of RNA pol II C-terminus 1	0.018	6	25.90	2	67
HEAT_2	HEAT repeats	4.3E-05	15	27.70	6	105
MMS19_N	NER and RNAPII transcription protein n terminal	3.8E-06	17	21.40	9	112
V-ATPase_H_C	V-ATPase subunit H	0.48	1	20.80	20	67
Dopey_N	Dopey, N-terminal	0.12	2	25.20	23	74
SEN1_N	SEN1 N terminal	0.44	-1	24.60	24	122
Adaptin_N	Adaptin N terminal region	0.18	1	20.30	37	71
Cnd1	non-SMC mitotic condensation complex subunit 1	0.022	5	26.40	38	111
HEAT	HEAT repeat	0.26	3	23.50	42	66
ParcG	Parkin co-regulated protein	0.2	2	20.60	45	88
Dopey_N	Dopey, N-terminal	0.13	2	25.20	47	115
CLASP_N	CLASP N terminal	3.2E-08	24	27.00	57	185
Vac14_Fab1_bd	Vacuolar 14 Fab1-binding region	8.6E-05	14	22.10	59	112
HEAT_EZ	HEAT-like repeat	8.1E-08	23	27.00	60	106
Tti2	Tti2 family	0.022	5	24.60	73	116
HEAT	HEAT repeat	0.0014	10	23.50	83	112
RTP1_C1	Required for nuclear transport of RNA pol II C-terminus 1	0.12	3	25.90	88	198
HEAT_EZ	HEAT-like repeat	2.4E-07	22	27.00	132	186
HEAT_2	HEAT repeats	0.00034	12	27.70	139	186
Vac14_Fab1_bd	Vacuolar 14 Fab1-binding region	0.093	4	22.10	145	179
DUF1981	Domain of unknown function (DUF1981)	0.022	5	20.90	156	192
V-ATPase_H_N	V-ATPase subunit H	0.36	1	20.10	157	201
Adaptin_N	Adaptin N terminal region	0.00038	10	20.30	157	197
DUF3361	Domain of unknown function (DUF3361)	0.23	2	27.20	157	201
Tti2	Tti2 family	0.066	3	24.60	159	186
Ecm29	Proteasome stabiliser	0.56	-1	20.70	159	180
MMS19_C	RNAPII transcription regulator C-terminal	0.47	0	32.90	160	193
HEAT	HEAT repeat	2.6E-07	21	23.50	160	186
Cnd1	non-SMC mitotic condensation complex subunit 1	0.00051	11	26.40	161	189
RasGEF_N_2	Rapamycin-insensitive companion of mTOR RasGEF_N domain	0.035	5	27.00	162	189
V-ATPase_H_C	V-ATPase subunit H	0.045	5	20.80	164	188
CLASP_N	CLASP N terminal	0	156	27.00	284	500
Cnd1	non-SMC mitotic condensation complex subunit 1	0.038	5	26.40	322	383
Sec7_N	Guanine nucleotide exchange factor in Golgi transport N-terminal	0.06	4	27.30	325	381
ParcG	Parkin co-regulated protein	0.71	1	20.60	327	361
Adaptin_N	Adaptin N terminal region	0.74	-1	20.30	346	405
Cnd1	non-SMC mitotic condensation complex subunit 1	0.24	2	26.40	445	473
Tti2	Tti2 family	0.077	3	24.60	748	870
V-ATPase_H_C	V-ATPase subunit H	0.09	4	20.80	790	864
CLASP_N	CLASP N terminal	3.4E-12	37	27.00	794	991
MMS19_N	NER and RNAPII transcription protein n terminal	0.028	4	21.40	796	885
ParcG	Parkin co-regulated protein	0.002	9	20.60	798	922
RTP1_C1	Required for nuclear transport of RNA pol II C-terminus 1	0.02	6	25.90	806	869
Ecm29	Proteasome stabiliser	0.39	0	20.70	809	939
Cnd1	non-SMC mitotic condensation complex subunit 1	0.0097	7	26.40	812	881
V-ATPase_H_N	V-ATPase subunit H	0.0042	7	20.10	815	901
HEAT_EZ	HEAT-like repeat	0.018	6	27.00	819	861
SEN1_N	SEN1 N terminal	8.5E-05	11	24.60	822	972
Vac14_Fab1_bd	Vacuolar 14 Fab1-binding region	0.028	6	22.10	830	896
Adaptin_N	Adaptin N terminal region	3.3E-05	13	20.30	834	991
Sec7_N	Guanine nucleotide exchange factor in Golgi transport N-terminal	0.01	6	27.30	835	915
DUF3361	Domain of unknown function (DUF3361)	0.98	0	27.20	836	873
RasGEF_N_2	Rapamycin-insensitive companion of mTOR RasGEF_N domain	0.012	7	27.00	837	866
HEAT	HEAT repeat	0.00014	13	23.50	837	867
HEAT_2	HEAT repeats	4.6E-05	14	27.70	840	932
MMS19_C	RNAPII transcription regulator C-terminal	0.14	2	32.90	841	891
HEAT	HEAT repeat	0.22	3	23.50	878	901
MMS19_N	NER and RNAPII transcription protein n terminal	0.37	1	21.40	904	946
MMS19_C	RNAPII transcription regulator C-terminal	0.9	-1	32.90	911	935
Ecm29	Proteasome stabiliser	0.77	-1	20.70	939	1036
DUF3361	Domain of unknown function (DUF3361)	0.011	6	27.20	1213	1314
Vac14_Fab1_bd	Vacuolar 14 Fab1-binding region	3.7E-06	18	22.10	1225	1313
Dopey_N	Dopey, N-terminal	0.047	3	25.20	1232	1290
MMS19_C	RNAPII transcription regulator C-terminal	0.0015	8	32.90	1242	1299
V-ATPase_H_C	V-ATPase subunit H	0.46	1	20.80	1242	1280
Tti2	Tti2 family	2.3E-05	15	24.60	1244	1284
ParcG	Parkin co-regulated protein	0.58	1	20.60	1248	1283
ParcG	Parkin co-regulated protein	0.59	1	20.60	1249	1304
V-ATPase_H_N	V-ATPase subunit H	0.00095	9	20.10	1249	1320
Sec7_N	Guanine nucleotide exchange factor in Golgi transport N-terminal	0.00024	12	27.30	1251	1302
Cnd1	non-SMC mitotic condensation complex subunit 1	0.00047	11	26.40	1251	1369
HEAT	HEAT repeat	0.13	4	23.50	1252	1280
RasGEF_N_2	Rapamycin-insensitive companion of mTOR RasGEF_N domain	0.64	1	27.00	1254	1300
Telomere_reg-2	Telomere length regulation protein	0.0025	9	20.90	1255	1336
RTP1_C1	Required for nuclear transport of RNA pol II C-terminus 1	0.039	5	25.90	1256	1305
Adaptin_N	Adaptin N terminal region	0.00089	8	20.30	1256	1392
HEAT_2	HEAT repeats	0.85	1	27.70	1257	1312
DUF1981	Domain of unknown function (DUF1981)	0.0017	9	20.90	1262	1316
Ecm29	Proteasome stabiliser	0.026	4	20.70	1262	1324
MMS19_N	NER and RNAPII transcription protein n terminal	0.22	2	21.40	1268	1330
CLASP_N	CLASP N terminal	1.4E-05	15	27.00	1271	1331
SEN1_N	SEN1 N terminal	0.5	-1	24.60	1282	1366
HEAT_2	HEAT repeats	0.25	2	27.70	1297	1354
MMS19_C	RNAPII transcription regulator C-terminal	0.0011	9	32.90	1329	1395
MMS19_N	NER and RNAPII transcription protein n terminal	0.23	2	21.40	1335	1375
ParcG	Parkin co-regulated protein	0.11	3	20.60	1336	1411
Dopey_N	Dopey, N-terminal	0.00035	10	25.20	1350	1411
HEAT_EZ	HEAT-like repeat	0.047	5	27.00	1356	1393
Ecm29	Proteasome stabiliser	0.0015	8	20.70	1359	1397
CLASP_N	CLASP N terminal	0.043	4	27.00	1360	1429
Vac14_Fab1_bd	Vacuolar 14 Fab1-binding region	0.031	6	22.10	1361	1421
HEAT_2	HEAT repeats	0.021	6	27.70	1369	1417
HEAT	HEAT repeat	0.00015	13	23.50	1370	1396