c2pfam

AT2G21280.1 :

Domain Description Evalue Bits GA Start End
RmlD_sub_bind RmlD substrate binding domain 0.00018 10 19.80 46 80
adh_short short chain dehydrogenase 2.6E-05 13 20.50 47 85
Semialdhyde_dh Semialdehyde dehydrogenase, NAD binding domain 2.9E-05 14 21.40 48 83
Polysacc_synt_2 Polysaccharide biosynthesis protein 0.00026 10 20.20 48 85
NmrA NmrA-like family 2.3E-07 20 20.60 48 99
Epimerase NAD dependent epimerase/dehydratase family 1.2E-20 64 20.60 49 265
NAD_binding_4 Male sterility protein 1.7E-07 20 20.10 50 82
3Beta_HSD 3-beta hydroxysteroid dehydrogenase/isomerase family 3.4E-07 19 20.00 50 145
GDP_Man_Dehyd GDP-mannose 4,6 dehydratase 4.9E-05 12 27.00 50 82
NAD_binding_10 NAD(P)H-binding 7.9E-11 32 27.20 52 176
Polysacc_synt_2 Polysaccharide biosynthesis protein 0.02 4 20.20 200 287
RmlD_sub_bind RmlD substrate binding domain 1 -2 19.80 201 222
GDP_Man_Dehyd GDP-mannose 4,6 dehydratase 0.022 4 27.00 238 271
DUF1731 Domain of unknown function (DUF1731) 3E-21 65 20.40 299 345

347

RmlD_sub_bind
adh_short
Semialdhyde_dh
Polysacc_synt_2
NmrA
Epimerase
NAD_binding_4
3Beta_HSD
GDP_Man_Dehyd
NAD_binding_10
Polysacc_synt_2
RmlD_sub_bind
GDP_Man_Dehyd
DUF1731

References:

DUF1731

Semialdhyde_dh
10369777 Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis. J Mol Biol 1999;289:991-1002.

adh_short
9735295 The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 A resolution. J Mol Biol 1998;282:383-399.
10387002 Structure of tropinone reductase-II complexed with NADP+ and pseudotropine at 1.9 A resolution: implication for stereospecific substrate binding and catalysis. Biochemistry 1999;38:7630-7637.

Epimerase
9174344 Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Biochemistry 1997;36:6294-6304.

GDP_Man_Dehyd

NAD_binding_4
9351246 The Arabidopsis MALE STERILITY 2 protein shares similarity with reductases in elongation/condensation complexes. Plant J 1997;12:615-623.

NmrA
11726498 The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases. EMBO J 2001;20:6619-6626.

3Beta_HSD
1562516 Structure and tissue-specific expression of 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues. J Steroid Biochem Mol Biol 1992;41:421-435.

Polysacc_synt_2
7961465 Sequence analysis and molecular characterization of genes required for the biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus. J Bacteriol 1994;176:7005-7016.
9079898 Identification of additional genes required for O-antigen biosynthesis in Vibrio cholerae O1. J Bacteriol 1997;179:2147-2153.

NAD_binding_10

RmlD_sub_bind
12057193 Variation on a Theme of SDR. dTDP-6-Deoxy-L- lyxo-4-Hexulose Reductase (RmlD) Shows a New Mg(2+)-Dependent Dimerization Mode. Structure (Camb) 2002;10:773-786.
10802738 RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase. Nat Struct Biol 2000;7:398-402.

Domain	Description	Evalue	Bits	GA	Start	End
RmlD_sub_bind	RmlD substrate binding domain	0.00018	10	19.80	46	80
adh_short	short chain dehydrogenase	2.6E-05	13	20.50	47	85
Semialdhyde_dh	Semialdehyde dehydrogenase, NAD binding domain	2.9E-05	14	21.40	48	83
Polysacc_synt_2	Polysaccharide biosynthesis protein	0.00026	10	20.20	48	85
NmrA	NmrA-like family	2.3E-07	20	20.60	48	99
Epimerase	NAD dependent epimerase/dehydratase family	1.2E-20	64	20.60	49	265
NAD_binding_4	Male sterility protein	1.7E-07	20	20.10	50	82
3Beta_HSD	3-beta hydroxysteroid dehydrogenase/isomerase family	3.4E-07	19	20.00	50	145
GDP_Man_Dehyd	GDP-mannose 4,6 dehydratase	4.9E-05	12	27.00	50	82
NAD_binding_10	NAD(P)H-binding	7.9E-11	32	27.20	52	176
Polysacc_synt_2	Polysaccharide biosynthesis protein	0.02	4	20.20	200	287
RmlD_sub_bind	RmlD substrate binding domain	1	-2	19.80	201	222
GDP_Man_Dehyd	GDP-mannose 4,6 dehydratase	0.022	4	27.00	238	271
DUF1731	Domain of unknown function (DUF1731)	3E-21	65	20.40	299	345