c2pfam

AT2G22125.1 :

Domain Description Evalue Bits GA Start End
Drf_GBD Diaphanous GTPase-binding Domain 0.012 4 21.30 60 134
HEAT_EZ HEAT-like repeat 0.033 4 27.00 104 133
Arm Armadillo/beta-catenin-like repeat 6.3E-08 22 20.60 104 134
HEAT_2 HEAT repeats 0.00029 11 27.70 108 174
HEAT HEAT repeat 0.016 5 23.50 108 135
HEAT_EZ HEAT-like repeat 0.014 5 27.00 122 171
Arm Armadillo/beta-catenin-like repeat 0.00019 11 20.60 147 171
HEAT HEAT repeat 0.039 4 23.50 149 177
UNC45-central Myosin-binding striated muscle assembly central 0.34 0 24.50 183 206
DUF3361 Domain of unknown function (DUF3361) 0.00098 8 27.20 228 330
Arm Armadillo/beta-catenin-like repeat 1.9E-05 14 20.60 231 257
V-ATPase_H_C V-ATPase subunit H 0.32 1 20.80 237 306
HEAT_2 HEAT repeats 0.00014 12 27.70 239 346
UNC45-central Myosin-binding striated muscle assembly central 0.00015 11 24.50 240 330
HEAT_EZ HEAT-like repeat 0.013 6 27.00 277 304
Arm Armadillo/beta-catenin-like repeat 0.056 3 20.60 277 308
HEAT HEAT repeat 0.032 4 23.50 282 307
Arm Armadillo/beta-catenin-like repeat 0.045 3 20.60 312 357
HEAT_EZ HEAT-like repeat 0.7 0 27.00 345 374
HEAT_2 HEAT repeats 0.22 1 27.70 425 478
DUF3361 Domain of unknown function (DUF3361) 0.00013 11 27.20 492 622
Arm Armadillo/beta-catenin-like repeat 0.68 0 20.60 494 516
Drf_GBD Diaphanous GTPase-binding Domain 0.15 1 21.30 514 563
Arm Armadillo/beta-catenin-like repeat 1.3E-08 24 20.60 524 563
HEAT_2 HEAT repeats 4.1E-05 13 27.70 537 623
HEAT_EZ HEAT-like repeat 0.9 0 27.00 537 562
Arm Armadillo/beta-catenin-like repeat 8.3E-05 12 20.60 567 604
UNC45-central Myosin-binding striated muscle assembly central 0.028 4 24.50 648 722
HEAT_2 HEAT repeats 0.0022 8 27.70 652 695
HEAT_EZ HEAT-like repeat 0.18 2 27.00 655 683
DUF3361 Domain of unknown function (DUF3361) 0.088 2 27.20 657 696
Arm Armadillo/beta-catenin-like repeat 0.00075 9 20.60 657 681
V-ATPase_H_C V-ATPase subunit H 0.52 0 20.80 673 686
Arm Armadillo/beta-catenin-like repeat 0.11 2 20.60 704 723
HEAT_EZ HEAT-like repeat 1 -1 27.00 738 768
Arm Armadillo/beta-catenin-like repeat 0.014 5 20.60 817 853
HEAT_2 HEAT repeats 0.75 0 27.70 817 861
Drf_GBD Diaphanous GTPase-binding Domain 0.19 1 21.30 875 906
HEAT_2 HEAT repeats 0.93 -1 27.70 879 906
HEAT_2 HEAT repeats 0.029 4 27.70 1097 1126
HEAT HEAT repeat 0.91 0 23.50 1102 1127
Arm Armadillo/beta-catenin-like repeat 0.87 -1 20.60 1197 1206
Arm Armadillo/beta-catenin-like repeat 1 -1 20.60 1234 1255
HEAT_2 HEAT repeats 0.0025 8 27.70 1298 1376
Arm Armadillo/beta-catenin-like repeat 0.017 5 20.60 1324 1350
HEAT_EZ HEAT-like repeat 0.29 1 27.00 1340 1355
Arm Armadillo/beta-catenin-like repeat 0.16 2 20.60 1364 1379
Arm Armadillo/beta-catenin-like repeat 0.014 5 20.60 1401 1432
HEAT_2 HEAT repeats 0.049 3 27.70 1406 1447
Arm Armadillo/beta-catenin-like repeat 0.013 5 20.60 1442 1474
Arm Armadillo/beta-catenin-like repeat 0.1 2 20.60 1482 1504
UNC45-central Myosin-binding striated muscle assembly central 0.017 4 24.50 1528 1604
DUF3361 Domain of unknown function (DUF3361) 0.088 2 27.20 1552 1609
Drf_GBD Diaphanous GTPase-binding Domain 0.023 4 21.30 1570 1605
HEAT_EZ HEAT-like repeat 4.5E-05 13 27.00 1578 1605
Arm Armadillo/beta-catenin-like repeat 3.4E-05 13 20.60 1578 1605
HEAT_2 HEAT repeats 9.2E-05 12 27.70 1578 1605
HEAT HEAT repeat 0.0028 8 23.50 1580 1606
Arm Armadillo/beta-catenin-like repeat 0.43 0 20.60 1613 1647
HEAT_2 HEAT repeats 0.12 2 27.70 1701 1752
Arm Armadillo/beta-catenin-like repeat 0.012 5 20.60 1702 1724
Arm Armadillo/beta-catenin-like repeat 0.0011 8 20.60 1738 1759
HEAT_2 HEAT repeats 0.0042 7 27.70 1744 1841
UNC45-central Myosin-binding striated muscle assembly central 0.0047 6 24.50 1764 1879
V-ATPase_H_C V-ATPase subunit H 1.3E-06 18 20.80 1822 1896
Arm Armadillo/beta-catenin-like repeat 0.0011 9 20.60 1825 1854
DUF3361 Domain of unknown function (DUF3361) 0.85 -1 27.20 1826 1863
HEAT_2 HEAT repeats 0.37 1 27.70 1829 1889
DUF3361 Domain of unknown function (DUF3361) 0.054 3 27.20 1834 1898
Arm Armadillo/beta-catenin-like repeat 6.5E-06 16 20.60 1859 1889
DUF3361 Domain of unknown function (DUF3361) 0.017 4 27.20 1867 1974
HEAT_2 HEAT repeats 0.3 1 27.70 1876 1977
HEAT_2 HEAT repeats 0.47 0 27.70 1955 1983
Arm Armadillo/beta-catenin-like repeat 0.00088 9 20.60 1955 1977
HEAT_EZ HEAT-like repeat 0.68 0 27.00 1955 1977
C2 C2 domain 2E-15 46 20.90 2030 2122

2150

Drf_GBD
HEAT_EZ
Arm
HEAT_2
HEAT
HEAT_EZ
Arm
HEAT
UNC45-central
DUF3361
Arm
V-ATPase_H_C
HEAT_2
UNC45-central
HEAT_EZ
Arm
HEAT
Arm
HEAT_EZ
HEAT_2
DUF3361
Arm
Drf_GBD
Arm
HEAT_2
HEAT_EZ
Arm
UNC45-central
HEAT_2
HEAT_EZ
DUF3361
Arm
V-ATPase_H_C
Arm
HEAT_EZ
Arm
HEAT_2
Drf_GBD
HEAT_2
HEAT_2
HEAT
Arm
Arm
HEAT_2
Arm
HEAT_EZ
Arm
Arm
HEAT_2
Arm
Arm
UNC45-central
DUF3361
Drf_GBD
HEAT_EZ
Arm
HEAT_2
HEAT
Arm
HEAT_2
Arm
Arm
HEAT_2
UNC45-central
V-ATPase_H_C
Arm
DUF3361
HEAT_2
DUF3361
Arm
DUF3361
HEAT_2
HEAT_2
Arm
HEAT_EZ
C2

References:

HEAT_2

UNC45-central
12356907 Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. J Cell Sci. 2002;115:4013-4023.
18523008 Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells. Proc Natl Acad Sci U S A. 2008;105:8014-8019.
18478096 Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain. PLoS ONE. 2008;3:e2137.

V-ATPase_H_C
10954728 Regulation of yeast ectoapyrase ynd1p activity by activator subunit Vma13p of vacuolar H+-ATPase. J Biol Chem 2000;275:35592-35599.
18708638 Functional characterization of the N-terminal domain of subunit H (Vma13p) of the yeast vacuolar ATPase. J Biol Chem. 2008; [Epub ahead of print]
16141210 Structural and functional separation of the N- and C-terminal domains of the yeast V-ATPase subunit H. J Biol Chem. 2005;280:36978-36985.

Arm
9298899 Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell 1997;90:871-882.
8573337 Signal transduction of beta-catenin. Curr Opin Cell Biol 1995;7:634-640.
9309175 Armadillo and dTCF: a marriage made in the nucleus. Curr Opin Genet Dev 1997;7:459-466.
8259519 Association of the APC tumor suppressor protein with catenins. Science 1993;262:1734-1737.
8259518 Association of the APC gene product with beta-catenin. Science 1993;262:1731-1734.
2261639 The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell 1990;63:1167-1176.

C2
8771209 Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin. Protein Sci 1996;5:162-166.

DUF3361

HEAT
7550332 HEAT repeats in the Huntington's disease protein. Nat Genet 1995;11:115-116.
9989501 The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell 1999;96:99-110.

Drf_GBD
12676083 Disruption of the Diaphanous-Related Formin Drf1 Gene Encoding mDia1 Reveals a Role for Drf3 as an Effector for Cdc42. Curr Biol 2003;13:534-545.

HEAT_EZ

Domain	Description	Evalue	Bits	GA	Start	End
Drf_GBD	Diaphanous GTPase-binding Domain	0.012	4	21.30	60	134
HEAT_EZ	HEAT-like repeat	0.033	4	27.00	104	133
Arm	Armadillo/beta-catenin-like repeat	6.3E-08	22	20.60	104	134
HEAT_2	HEAT repeats	0.00029	11	27.70	108	174
HEAT	HEAT repeat	0.016	5	23.50	108	135
HEAT_EZ	HEAT-like repeat	0.014	5	27.00	122	171
Arm	Armadillo/beta-catenin-like repeat	0.00019	11	20.60	147	171
HEAT	HEAT repeat	0.039	4	23.50	149	177
UNC45-central	Myosin-binding striated muscle assembly central	0.34	0	24.50	183	206
DUF3361	Domain of unknown function (DUF3361)	0.00098	8	27.20	228	330
Arm	Armadillo/beta-catenin-like repeat	1.9E-05	14	20.60	231	257
V-ATPase_H_C	V-ATPase subunit H	0.32	1	20.80	237	306
HEAT_2	HEAT repeats	0.00014	12	27.70	239	346
UNC45-central	Myosin-binding striated muscle assembly central	0.00015	11	24.50	240	330
HEAT_EZ	HEAT-like repeat	0.013	6	27.00	277	304
Arm	Armadillo/beta-catenin-like repeat	0.056	3	20.60	277	308
HEAT	HEAT repeat	0.032	4	23.50	282	307
Arm	Armadillo/beta-catenin-like repeat	0.045	3	20.60	312	357
HEAT_EZ	HEAT-like repeat	0.7	0	27.00	345	374
HEAT_2	HEAT repeats	0.22	1	27.70	425	478
DUF3361	Domain of unknown function (DUF3361)	0.00013	11	27.20	492	622
Arm	Armadillo/beta-catenin-like repeat	0.68	0	20.60	494	516
Drf_GBD	Diaphanous GTPase-binding Domain	0.15	1	21.30	514	563
Arm	Armadillo/beta-catenin-like repeat	1.3E-08	24	20.60	524	563
HEAT_2	HEAT repeats	4.1E-05	13	27.70	537	623
HEAT_EZ	HEAT-like repeat	0.9	0	27.00	537	562
Arm	Armadillo/beta-catenin-like repeat	8.3E-05	12	20.60	567	604
UNC45-central	Myosin-binding striated muscle assembly central	0.028	4	24.50	648	722
HEAT_2	HEAT repeats	0.0022	8	27.70	652	695
HEAT_EZ	HEAT-like repeat	0.18	2	27.00	655	683
DUF3361	Domain of unknown function (DUF3361)	0.088	2	27.20	657	696
Arm	Armadillo/beta-catenin-like repeat	0.00075	9	20.60	657	681
V-ATPase_H_C	V-ATPase subunit H	0.52	0	20.80	673	686
Arm	Armadillo/beta-catenin-like repeat	0.11	2	20.60	704	723
HEAT_EZ	HEAT-like repeat	1	-1	27.00	738	768
Arm	Armadillo/beta-catenin-like repeat	0.014	5	20.60	817	853
HEAT_2	HEAT repeats	0.75	0	27.70	817	861
Drf_GBD	Diaphanous GTPase-binding Domain	0.19	1	21.30	875	906
HEAT_2	HEAT repeats	0.93	-1	27.70	879	906
HEAT_2	HEAT repeats	0.029	4	27.70	1097	1126
HEAT	HEAT repeat	0.91	0	23.50	1102	1127
Arm	Armadillo/beta-catenin-like repeat	0.87	-1	20.60	1197	1206
Arm	Armadillo/beta-catenin-like repeat	1	-1	20.60	1234	1255
HEAT_2	HEAT repeats	0.0025	8	27.70	1298	1376
Arm	Armadillo/beta-catenin-like repeat	0.017	5	20.60	1324	1350
HEAT_EZ	HEAT-like repeat	0.29	1	27.00	1340	1355
Arm	Armadillo/beta-catenin-like repeat	0.16	2	20.60	1364	1379
Arm	Armadillo/beta-catenin-like repeat	0.014	5	20.60	1401	1432
HEAT_2	HEAT repeats	0.049	3	27.70	1406	1447
Arm	Armadillo/beta-catenin-like repeat	0.013	5	20.60	1442	1474
Arm	Armadillo/beta-catenin-like repeat	0.1	2	20.60	1482	1504
UNC45-central	Myosin-binding striated muscle assembly central	0.017	4	24.50	1528	1604
DUF3361	Domain of unknown function (DUF3361)	0.088	2	27.20	1552	1609
Drf_GBD	Diaphanous GTPase-binding Domain	0.023	4	21.30	1570	1605
HEAT_EZ	HEAT-like repeat	4.5E-05	13	27.00	1578	1605
Arm	Armadillo/beta-catenin-like repeat	3.4E-05	13	20.60	1578	1605
HEAT_2	HEAT repeats	9.2E-05	12	27.70	1578	1605
HEAT	HEAT repeat	0.0028	8	23.50	1580	1606
Arm	Armadillo/beta-catenin-like repeat	0.43	0	20.60	1613	1647
HEAT_2	HEAT repeats	0.12	2	27.70	1701	1752
Arm	Armadillo/beta-catenin-like repeat	0.012	5	20.60	1702	1724
Arm	Armadillo/beta-catenin-like repeat	0.0011	8	20.60	1738	1759
HEAT_2	HEAT repeats	0.0042	7	27.70	1744	1841
UNC45-central	Myosin-binding striated muscle assembly central	0.0047	6	24.50	1764	1879
V-ATPase_H_C	V-ATPase subunit H	1.3E-06	18	20.80	1822	1896
Arm	Armadillo/beta-catenin-like repeat	0.0011	9	20.60	1825	1854
DUF3361	Domain of unknown function (DUF3361)	0.85	-1	27.20	1826	1863
HEAT_2	HEAT repeats	0.37	1	27.70	1829	1889
DUF3361	Domain of unknown function (DUF3361)	0.054	3	27.20	1834	1898
Arm	Armadillo/beta-catenin-like repeat	6.5E-06	16	20.60	1859	1889
DUF3361	Domain of unknown function (DUF3361)	0.017	4	27.20	1867	1974
HEAT_2	HEAT repeats	0.3	1	27.70	1876	1977
HEAT_2	HEAT repeats	0.47	0	27.70	1955	1983
Arm	Armadillo/beta-catenin-like repeat	0.00088	9	20.60	1955	1977
HEAT_EZ	HEAT-like repeat	0.68	0	27.00	1955	1977
C2	C2 domain	2E-15	46	20.90	2030	2122